ReviewNature reviews. Nephrology2015
Early chronic kidney disease: diagnosis, management and models of care.
Review in Nature reviews. Nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
104 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Advanced age is significantly associated with poor outcomes of thoracic endovascular aortic repair: a systematic review and meta-analysis.BMC surgery · 2025Pooled it
- Functional magnetic resonance imaging for staging chronic kidney disease: a systematic review and meta-analysis.International urology and nephrology · 2024Pooled it
- Translating CKD Research into Primary Care Practice: a Group-Randomized Study.Journal of general internal medicine · 2020Trial
- Early renal dysfunction and fibroblast growth factor-23 in patients with small vessel disease-related stroke.Scientific reports · 2019Trial
- A Microsimulation-Based Approach for Mitigating Societal Bias in Chronic Kidney Disease Data.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- From comics to care: exploring the education potential of graphic novel in organ transplantation journey.Medical humanities · 2026Article
- Causal modeling of chronic kidney disease in a participatory framework for informing the inclusion of social drivers in health algorithms.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Leveraging ICT Tools to Improve Kidney Health: A Comprehensive Review of Innovations in Nephrology.Healthcare (Basel, Switzerland) · 2026Review
- The role of social networks in supporting self-management in CKD: a narrative synthesis.BMC nephrology · 2025Review
- A microsimulation-based framework for mitigating societal bias in primary care data.medRxiv : the preprint server for health sciences · 2025Article
- Causal modeling of chronic kidney disease in a participatory framework for informing the inclusion of social drivers in health algorithms.medRxiv : the preprint server for health sciences · 2025Article
- Handheld Lab-on-a-Chip System for Label-Free Dual-Plex Detection of Biomarkers Through On-Chip Plasma Separation.Biosensors · 2025Article
- Investigating the patterns of renal function variability in early-stage chronic kidney disease by cluster analysis.BMC nephrology · 2025Article
- Explainable machine learning model incorporating social determinants of health to predict chronic kidney disease in type 2 diabetes patients.Journal of diabetes and metabolic disorders · 2025Article
- Incorporating area-level social drivers of health in predictive algorithms using electronic health record data.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- A recursive embedding and clustering technique for unraveling asymptomatic kidney disease using laboratory data and machine learning.Scientific reports · 2025Article
- Article
- Renal fat deposition measured on dixon-based MRI is significantly associated with early kidney damage in obesity.Abdominal radiology (New York) · 2024Article
- Mathematical Models for Ultrasound Elastography: Recent Advances to Improve Accuracy and Clinical Utility.Bioengineering (Basel, Switzerland) · 2024Review
- Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Chronic kidney disease (CKD) is prevalent in many countries, and the costs associated with the care of patients with end-stage renal disease (ESRD) are estimated to exceed US$1 trillion globally. The clinical and economic rationale for the design of timely and appropriate health system responses to limit the progression of CKD to ESRD is clear. Clinical care might improve if early-stage CKD with risk of progression to ESRD is differentiated from early-stage CKD that is unlikely to advance. The diagnostic tests that are currently used for CKD exhibit key limitations; therefore, additional research is required to increase awareness of the risk factors for CKD progression. Systems modelling can be used to evaluate the impact of different care models on CKD outcomes and costs. The US Indian Health Service has demonstrated that an integrated, system-wide approach can produce notable benefits on cardiovascular and renal health outcomes. Economic and clinical improvements might, therefore, be possible if CKD is reconceptualized as a part of primary care. This Review discusses which early CKD interventions are appropriate, the optimum time to provide clinical care, and the most suitable model of care to adopt.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.