ArticleBiomechanics and modeling in mechanobiology2016
A triphasic constrained mixture model of engineered tissue formation under in vitro dynamic mechanical conditioning.
Article in Biomechanics and modeling in mechanobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Computer-aided engineering and additive manufacturing for bioreactors in tissue engineering: State of the art and perspectives.Biophysics reviews · 2023Review
- Reducing retraction in engineered tissues through design of sequential growth factor treatment.Biofabrication · 2023Article
- Silk fibroin microgels as a platform for cell microencapsulation.Journal of materials science. Materials in medicine · 2022Article
- Constrained Mixture Models of Soft Tissue Growth and Remodeling - Twenty Years After.Journal Of Elasticity · 2021Article
- Computational models of cardiac hypertrophy.Progress in biophysics and molecular biology · 2021Review
- Computational modeling for cardiovascular tissue engineering: the importance of including cell behavior in growth and remodeling algorithms.Current opinion in biomedical engineering · 2020Review
- Correction of bias in the estimation of cell volume fraction from histology sections.Journal of biomechanics · 2020Article
- Growth and remodelling of living tissues: perspectives, challenges and opportunities.Journal of the Royal Society, Interface · 2019Review
- Mechanobiological Stability of Biological Soft Tissues.Journal of the mechanics and physics of solids · 2019Article
- Critical roles of time-scales in soft tissue growth and remodeling.APL bioengineering · 2018Article
- Reactive Constrained Mixtures for Modeling the Solid Matrix of Biological Tissues.Journal Of Elasticity · 2017Article
- Cellular Microbiaxial Stretching to Measure a Single-Cell Strain Energy Density Function.Journal of biomechanical engineering · 2017Article
- A mathematical model for the determination of forming tissue moduli in needled-nonwoven scaffolds.Acta biomaterialia · 2017Article
- Large strain stimulation promotes extracellular matrix production and stiffness in an elastomeric scaffold model.Journal of the mechanical behavior of biomedical materials · 2016Article
- Mathematical and computational models for bone tissue engineering in bioreactor systems.Journal of tissue engineeringArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
While it has become axiomatic that mechanical signals promote in vitro engineered tissue formation, the underlying mechanisms remain largely unknown. Moreover, efforts to date to determine parameters for optimal extracellular matrix (ECM) development have been largely empirical. In the present work, we propose a two-pronged approach involving novel theoretical developments coupled with key experimental data to develop better mechanistic understanding of growth and development of dense connective tissue under mechanical stimuli. To describe cellular proliferation and ECM synthesis that occur at rates of days to weeks, we employ mixture theory to model the construct constituents as a nutrient-cell-ECM triphasic system, their transport, and their biochemical reactions. Dynamic conditioning protocols with frequencies around 1 Hz are described with multi-scale methods to couple the dissimilar time scales. Enhancement of nutrient transport due to pore fluid advection is upscaled into the growth model, and the spatially dependent ECM distribution describes the evolving poroelastic characteristics of the scaffold-engineered tissue construct. Simulation results compared favorably to the existing experimental data, and most importantly, distinguish between static and dynamic conditioning regimes. The theoretical framework for mechanically conditioned tissue engineering (TE) permits not only the formulation of novel and better-informed mechanistic hypothesis describing the phenomena underlying TE growth and development, but also the exploration/optimization of conditioning protocols in a rational manner.
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Registered trials
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