ArticleBMC nephrology2015
End stage renal disease as a modifier of the periodontal microbiome.
Article in BMC nephrology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01094639 (Periodontal Infection and Systemic Inflammation in Renal Patients), which is not on this map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Periodontal Infection and Systemic Inflammation in Renal Patients
Who cites it
15 citing papers in PubMed.
- Association of periodontitis with reduced kidney function and albuminuria in early chronic kidney disease: a population-based study.International journal of oral science · 2026Article
- Patient-related factors that link chronic kidney disease and periodontitis: a scoping review.Odontology · 2025Article
- Oral dysbiosis initiates periodontal disease in experimental kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Fistula first, catheter last: can the mouth be second?Frontiers in nephrology · 2024Article
- [Research Progress in the Correlation Between Oral Microbiota and Chronic Kidney Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Transplantation impacts on the oral microbiome of kidney recipients and donors.Frontiers in microbiomes · 2023Article
- Difference in oral microbiota composition between patients with stage 5 chronic kidney disease on hemodialysis and healthy controls.American journal of translational research · 2023Article
- Characteristics of human oral microbiome and its non-invasive diagnostic value in chronic kidney disease.Bioscience reports · 2022Article
- The frequency of periodontitis in end-stage renal disease on hemodialysis in a sample of Egyptian population: multi-center clinical cross-sectional study.BMC oral health · 2022Article
- Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis.BMC nephrology · 2020Article
- Discriminating Microbial Community Structure Between Peri-Implantitis and Periodontitis With Integrated Metagenomic, Metatranscriptomic, and Network Analysis.Frontiers in cellular and infection microbiology · 2020Article
- Microbiome-metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease.Cellular and molecular life sciences : CMLS · 2019Article
- Unilateral ureteral obstruction causes gut microbial dysbiosis and metabolome disorders contributing to tubulointerstitial fibrosis.Experimental & molecular medicine · 2019Article
- Location-Specific Oral Microbiome Possesses Features Associated With CKD.Kidney international reports · 2018Article
- Structural and functional differences in gut microbiome composition in patients undergoing haemodialysis or peritoneal dialysis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
backgroundEvidence supports high prevalence of periodontitis in patients with chronic kidney disease. Several renal factors have been proposed as possible modifiers of periodontitis pathogenesis in this population. In this cross sectional study, we investigated whether distinct microbial profiles in renal patients could explain high periodontitis prevalence.
methodsWe characterized the subgingival microbiome in 14 End Stage Renal Disease (ESRD) and 13 control individuals with chronic periodontitis with similar demographic and clinical parameters. Medical, demographic and periodontal parameters were recorded. Subgingival biofilm samples were collected from the deepest pocket in two different quadrants and characterized via 454-pyrosequencing of the 16S rRNA gene.
resultsWe found 874 species-level operational taxonomic units (OTU) across samples. Renal and control groups did not differ in the individual proportions of periodontitis-associated taxa. However, in principal coordinate plots of distance among samples based on OTU prevalence, some renal patients clustered apart from controls, with the microbial communities of these outlier subjects showing less diversity. Univariate correlation analysis showed a significant negative correlation between dialysis vintage and community diversity.
conclusionsWithin the study limitations, dialysis vintage was associated with a less diverse periodontal microbial community in ESRD suggesting the need for further research.
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