ArticleAnnals of intensive care2015
Feeding critically ill patients the right 'whey': thinking outside of the box. A personal view.
Article in Annals of intensive care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time to Protein Target, the 'HIGH WHEY' Study A Prospective Pilot Study
Comparison of Time-restricted Feeding and Continuous Feeding in Critically Ill Patients
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Effects of continuous versus intermittent enteral feeding on feeding tolerance in critically ill adults: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Clinical efficacy of enteral nutrition feeding modalities in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.European journal of clinical nutrition · 2023Pooled it
- Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis.Critical care (London, England) · 2022Pooled it
- Intermittent enteral nutrition shortens the time to achieve nutritional goals in critically ill patients.Scientific reports · 2025Trial
- Association of admission cortisol levels with outcomes and treatment response in patients at nutritional risk : A secondary analysis of a randomized clinical trial.Nutrition journal · 2023Trial
- Intermittent versus continuous tube feeding in patients with hemorrhagic stroke: a randomized controlled clinical trial.European journal of clinical nutrition · 2020Trial
- Association of Baseline Inflammation With Effectiveness of Nutritional Support Among Patients With Disease-Related Malnutrition: A Secondary Analysis of a Randomized Clinical Trial.JAMA network open · 2020Trial
- A randomized controlled trial examining the impact of diversified nursing interventions on the circadian rhythm of sedated critically ill patients.Frontiers in medicine · 2025Article
- The effect of intermittent versus continuous enteral feeding for critically ill patients: a meta-analysis of randomized controlled trials.Frontiers in nutrition · 2023Review
- Unsuitability of sump tubes for delivery of enteral nutrition and medications to intensive care unit patients.Proceedings (Baylor University. Medical Center) · 2021Article
- Serotonin-Its Synthesis and Roles in the Healthy and the Critically Ill.International journal of molecular sciences · 2021Review
- [Clinical guidelines for the diagnosis and treatment of neonatal necrotizing enterocolitis (2020)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Article
- Article
- Gastrointestinal Dysfunction and Feeding Intolerance in Critical Illness: Do We Need an Objective Scoring System?Current gastroenterology reports · 2020Review
- High protein intake during the early phase of critical illness: yes or no?Critical care (London, England) · 2018Article
- Clinical chronobiology: a timely consideration in critical care medicine.Critical care (London, England) · 2018Review
- Current perspective for tube feeding in the elderly: from identifying malnutrition to providing of enteral nutrition.Clinical interventions in aging · 2018Review
- The intensive care medicine research agenda in nutrition and metabolism.Intensive care medicine · 2017Review
- The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review.Critical care (London, England) · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atrophy of skeletal muscle mass is an almost universal problem in survivors of critical illness and is associated with significant short- and long-term morbidity. Contrary to common practice, the provision of protein/amino acids as a continuous infusion significantly limits protein synthesis whereas intermittent feeding maximally stimulates skeletal muscle synthesis. Furthermore, whey-based protein (high in leucine) increases muscle synthesis compared to soy or casein-based protein. In addition to its adverse effects on skeletal muscle synthesis, continuous feeding is unphysiological and has adverse effects on glucose and lipid metabolism and gastrointestinal function. I propose that critically ill patients' be fed intermittently with a whey-based formula and that such an approach is likely to be associated with better glycemic control, less hepatic steatosis and greater preservation of muscle mass. This paper provides the scientific basis for my approach to intermittent feeding of critically ill patients.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.