Evidence map›Paper›PMID 26055178›Full record

ArticleTranslational oncology2015

Background Parenchymal Enhancement of the Contralateral Normal Breast: Association with Tumor Response in Breast Cancer Patients Receiving Neoadjuvant Chemotherapy.

Jeon Hor Chen, Hon J Yu, Christine Hsu, Rita S Mehta, Philip M Carpenter, Min Ying Su

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PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  10. New Frontiers in Breast Cancer Imaging: The Rise of AI.Bioengineering (Basel, Switzerland) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jeon Hor ChenCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USA; Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan. Electronic address: jeonhc@uci.edu.
Hon J YuCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USA.
Christine HsuCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USA.
Rita S MehtaDepartment of Medicine, University of California, Irvine, Irvine, CA, USA.
Philip M CarpenterDepartment of Pathology, University of California, Irvine, Irvine, CA, USA.
Min Ying SuCenter for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, Irvine, CA, USA.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Prediction of Neoadjuvant Chemo Pathological Response Using MRI MarkersR01CA127927 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI SU, MIN-YING L. · 2008 to 2017
$5.0M
Volume and Morphology of Fibroglandular Tissue for Breast Cancer Risk PredictionR21CA170955 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, JEON-HOR, SU, MIN-YING L. · 2013 to 2014
$363k
Evaluation of 3D MRI-Based Quantitative Breast Density for ChemopreventionR03CA136071 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, JEON-HOR · 2009 to 2010
$153k
NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA127927NCI NIH HHS R03 CA136071NCI NIH HHS R21 CA170955
6 · The paper itself

Abstract

purposeThis study investigated the association between background parenchymal enhancement (BPE) and pathologic response to neoadjuvant chemotherapy (NAC).

methodsA total of 46 patients diagnosed with invasive breast cancer were analyzed. Each patient had three magnetic resonance imaging (MRI) studies, one pre-treatment and two follow-up (F/U) MRI studies. BPE was measured as the averaged enhancement of the whole fibroglandular tissues. The pre-treatment BPE and the changes in the F/U MRI were compared between patients achieving pathologic complete response (pCR) versus those not. Subgroup analyses based on age, estrogen receptor (ER), and human epidermal growth factor receptor 2 (HER2) status of their cancers were also performed.

resultsThe pre-treatment BPE was higher in the pCR group than that in the non-pCR group. Compared to baseline, BPE at F/U-1 was significantly decreased in the pCR group but not in the non-pCR group. In subgroup analysis based on age, these results were seen only in the younger group (<55 years old), not in the older group (≥55 years old). Older patients had a significantly lower pre-treatment BPE than younger patients. In analysis based on molecular biomarkers, a significantly decreased BPE at F/U-1 was only found in the ER-negative pCR group but not in the non-pCR, nor in the ER-positive groups.

conclusionsA higher pre-treatment BPE showing a significant decrease early after starting NAC was related to pCR in pre/peri-menopausal patients.

Identifiers

PMID26055178
PMCPMC4487259

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.