Evidence map›Paper›PMID 26055111›Full record

ReviewJournal of bacteriology2016

Bacterial Signal Transduction by Cyclic Di-GMP and Other Nucleotide Second Messengers.

Regine Hengge, Angelika Gründling, Urs Jenal, Robert Ryan, Fitnat Yildiz

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of bacteriology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 154 citations in OpenAlex.

  1. Article
  2. Article
  3. bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. A novelVirulence · 2025
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  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Prokaryotic homeostasis - a solution to thrive and survive.Frontiers in molecular biosciences · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Functional analysis of cyclic diguanylate-modulating proteins inbioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Regine Hengge
Angelika Gründling
Urs Jenal
Robert Ryan
Fitnat Yildiz
Humboldt-Universität zu Berlin · DEImperial College London · GBUniversity of Basel · CHUniversity of California, Santa Cruz · USUniversity of Dundee · GB

Funding

Medical Research Council MR/J006874/1Wellcome Trust 100289
6 · The paper itself

Abstract

The first International Symposium on c-Di-GMP Signaling in Bacteria (22 to 25 March 2015, Harnack-Haus, Berlin, Germany)brought together 131 molecular microbiologists from 17 countries to discuss recent progress in our knowledge of bacterial nucleotide second messenger signaling. While the focus was on signal input, synthesis, degradation, and the striking diversity of the modes of action of the current second messenger paradigm, i.e., cyclic di-GMP (c-di-GMP), “classics” like cAMP and (p)ppGpp were also presented, in novel facets, and more recent “newcomers,” such as c-di-AMP and c-AMP-GMP, made an impressive appearance. A number of clear trends emerged during the 30 talks, on the 71 posters, and in the lively discussions, including (i)c-di-GMP control of the activities of various ATPases and phosphorylation cascades, (ii) extensive cross talk between c-di-GMP and other nucleotide second messenger signaling pathways, and (iii) a stunning number of novel effectors for nucleotide second messengers that surprisingly include some long-known master regulators of developmental pathways. Overall, the conference made it amply clear that second messenger signaling is currently one of the most dynamic fields within molecular microbiology,with major impacts in research fields ranging from human health to microbial ecology.

Indexed as

BacteriaBacterial ProteinsCyclic GMPGene Expression Regulation, BacterialSecond Messenger SystemsSignal TransductionBacterial Proteinsbis(3',5')-cyclic diguanylic acidCyclic GMP

Identifiers

PMID26055111
PMCPMC4686208
OpenAlexW633326766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.