Evidence map›Paper›PMID 26055058›Full record

ReviewProgress in molecular biology and translational science2015

Trafficking of β-Adrenergic Receptors: Implications in Intracellular Receptor Signaling.

Qin Fu, Yang K Xiang

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Progress in molecular biology and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Exosome: an overview on enhanced biogenesis by small molecules.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  7. Implication of Central βArchiv der Pharmazie · 2025
    Review
  8. Article
  9. β-Adrenergic Signaling Promotes Morphological Maturation of Astrocytes in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  10. Article
  11. Article
  12. Aging of Vascular System Is a Complex Process: The Cornerstone Mechanisms.International journal of molecular sciences · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Insulin and β Adrenergic Receptor Signaling: Crosstalk in Heart.Trends in endocrinology and metabolism: TEM · 2017
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Qin FuDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Yang K XiangDepartment of Pharmacology, University of California, Davis California, USA. Electronic address: ykxiang@ucdavis.edu.
Huazhong University of Science and Technology · CNUniversity of California, Davis · US

Funding

Spatiotemporal regulation of beta adrenoceptor signaling in cardiacmyocytesR01HL082846 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI XIANG, YANG K · 2006 to 2014
$3.0M
NHLBI NIH HHS R01 HL082846
6 · The paper itself

Abstract

β-Adrenergic receptors (βARs), prototypical G-protein-coupled receptors, play a pivotal role in regulating neuronal and cardiovascular responses to catecholamines during stress. Agonist-induced receptor endocytosis is traditionally considered as a primary mechanism to turn off the receptor signaling (or receptor desensitization). However, recent progress suggests that intracellular trafficking of βAR presents a mean to translocate receptor signaling machinery to intracellular organelles/compartments while terminating the signaling at the cell surface. Moreover, the apparent multidimensionality of ligand efficacy in space and time in a cell has forecasted exciting pathophysiological implications, which are just beginning to be explored. As we begin to understand how these pathways impact downstream cellular programs, this will have significant implications for a number of pathophysiological conditions in heart and other systems, that in turn open up new therapeutic opportunities.

Indexed as

Signal TransductionAnimalsArrestinsbeta-ArrestinsCaveolin 3Cell MembraneEndocytosisEndosomesHeart FailureHumansLigandsMembrane MicrodomainsMyocytes, CardiacProtein BindingProtein TransportReceptors, Adrenergic, betaArrestinsbeta-ArrestinsCaveolin 3LigandsReceptors, Adrenergic, betaArrestinBeta adrenergic receptorCardiac myocyteEndosomeG-protein

Identifiers

PMID26055058
PMCPMC7328190
OpenAlexW2466871656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.