Evidence map›Paper›PMID 26054936›Full record

ArticlePsychiatry research2015

Web-based phenotyping for Tourette Syndrome: Reliability of common co-morbid diagnoses.

Sabrina M Darrow, Cornelia Illmann, Caitlin Gauvin, Lisa Osiecki, Crystelle A Egan, Erica Greenberg, Monika Eckfield, Matthew E Hirschtritt, David L Pauls, James R Batterson and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Door-to-door Video-Enhanced Prevalence Study of Tourette Disorder Among African Americans.Evidence-based practice in child and adolescent mental health · 2024
    Article
  6. Article
  7. Autism Spectrum Symptoms in a Tourette's Disorder Sample.Journal of the American Academy of Child and Adolescent Psychiatry · 2017
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sabrina M DarrowDepartment of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA.
Cornelia IllmannPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA.
Caitlin GauvinPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA.
Lisa OsieckiPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA.
Crystelle A EganMartinez Outpatient Clinic and Community Living Center, Northern California VA Health Care System, 150 Muir Road, Martinez, CA 94553, USA.
Erica GreenbergPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA.
Monika EckfieldDepartment of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA; School of Nursing, University of California San Francisco, 2 Koret Way #N-319X, San Francisco, CA 94143, USA; Department of Nursing and Health Sciences, California State University East Bay 25800 Carlos Bee Blvd., Hayward, CA 94542, USA.
Matthew E HirschtrittDepartment of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA.
David L PaulsPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA.
James R BattersonChildren's Mercy Hospitals & Clinics, University of Missouri, Kansas City School of Medicine, 2401 Gilham Road, Kansas City, MO 64108, USA.
Cheston M BerlinMilton S. Hershey Medical Center, College of Medicine, Pennsylvania State, 500 University Dr., Hershey, PA 17033, USA.
Irene A MalatyUF Center for Movement Disorders and Neurorestoration, Department of Neurology, College of Medicine, University of Florida, 3450 Hull Road, Gainesville, FL 32607, USA.
Douglas W WoodsDepartment of Psychology, Texas A&M University, 4235 TAMU, College Station, TX 77843, USA.
Jeremiah M ScharfPsychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetics Research, Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 185 Cambridge St., Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, 415 Main St., Cambridge, MA 02142, USA; Division of Cognitive and Behavioral Neurology, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115, USA; Department of Neurology, Massachusetts General Hospital, 55 Fruit St., Boston, MA 02114, USA.
Carol A MathewsDepartment of Psychiatry, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: cmathews@lppi.ucsf.edu.

Funding

GENETICS OF TOURETTE SYNDROMER01NS016648 · NINDS · YALE UNIVERSITY · PI PAULS, DAVID L · 1985 to 2009
$9.0M
A Genetic Linkage Study of GTSU01NS040024 · NINDS · TOURETTE ASSOCIATION OF AMERICA, INC. · PI SCHARF, JEREMIAH M · 2007 to 2012
$8.0M
TRAINING THE NEXT GENERATION OF MENTAL HEALTH RESEARCHERSR25MH060482 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL H MATHALON, Susan M. Voglmaier · 2000 to 2026
$5.2M
Refining the Tourette Syndrome phenotype across diagnoses to aid gene discoveryR01MH096767 · NIMH · UNIVERSITY OF FLORIDA · PI MATHEWS, CAROL A · 2013 to 2015
$1.2M
Translational phenomics and genomics of Gilles de la Tourette SyndromeK23MH085057 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI SCHARF, JEREMIAH M · 2009 to 2013
$929k
GENETICS OF A BEHAVIORAL DISORDER;TOURETTE SYNDROME (RG)K02MH000508 · NIMH · YALE UNIVERSITY · PI PAULS, DAVID L · 1985 to 1993
–
NEUROPSYCHOLOGICAL EVALUATION OF PSYCHIATRIC AND NEUROLOGICAL PATIENTSZ01MH000508 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MIRSKY, ALLAN F. · 1985 to 2006
–
Intramural NIH HHS Z01 MH000508NIMH NIH HHS K02MH00508NIMH NIH HHS K23 MH085057NIMH NIH HHS K23MH085057NIMH NIH HHS R01 MH096767NIMH NIH HHS R01MH096767NIMH NIH HHS R25 MH060482NINDS NIH HHS R01 NS016648NINDS NIH HHS R01NS016648NINDS NIH HHS U01 NS040024NINDS NIH HHS U01NS040024
6 · The paper itself

Abstract

Collecting phenotypic data necessary for genetic analyses of neuropsychiatric disorders is time consuming and costly. Development of web-based phenotype assessments would greatly improve the efficiency and cost-effectiveness of genetic research. However, evaluating the reliability of this approach compared to standard, in-depth clinical interviews is essential. The current study replicates and extends a preliminary report on the utility of a web-based screen for Tourette Syndrome (TS) and common comorbid diagnoses (obsessive compulsive disorder (OCD) and attention deficit/hyperactivity disorder (ADHD)). A subset of individuals who completed a web-based phenotyping assessment for a TS genetic study was invited to participate in semi-structured diagnostic clinical interviews. The data from these interviews were used to determine participants' diagnostic status for TS, OCD, and ADHD using best estimate procedures, which then served as the gold standard to compare diagnoses assigned using web-based screen data. The results show high rates of agreement for TS. Kappas for OCD and ADHD diagnoses were also high and together demonstrate the utility of this self-report data in comparison previous diagnoses from clinicians and dimensional assessment methods.

Indexed as

InternetMass ScreeningPhenotypeAdolescentAdultAttention Deficit Disorder with HyperactivityChildComorbidityFemaleGenetic TestingHumansInterview, PsychologicalMaleObsessive-Compulsive DisorderReproducibility of ResultsTourette SyndromeAttention deficit/hyperactivity disorderObsessive–compulsive disorderTourette SyndromeWeb-based assessment

Identifiers

PMID26054936
PMCPMC4532555

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.