ArticleEuropean journal of nuclear medicine and molecular imaging2015
The impact of obesity on the relationship between epicardial adipose tissue, left ventricular mass and coronary microvascular function.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Correlation Between Epicardial Adipose Tissue and PET Cardiac Perfusion: A Systematic Review.Medical sciences (Basel, Switzerland) · 2026Pooled it
- Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function.Journal of the American Heart Association · 2018Pooled it
- Radiomics of baseline epicardial adipose tissue predicts left ventricular mass regression after transcatheter aortic valve replacement.Journal of geriatric cardiology : JGC · 2024Article
- Association of epicardial adipose tissue volume with heart weight in post-mortem cases.Forensic science, medicine, and pathology · 2024Article
- Association of Cardiovascular Risk Factors and Coronary Calcium Burden with Epicardial Adipose Tissue Volume Obtained from PET-CT Imaging in Oncological Patients.Journal of cardiovascular development and disease · 2024Article
- Metabolic interactions between organs in overweight and obesity using total-body positron emission tomography.International journal of obesity (2005) · 2024Article
- Epicardial adipose tissue in patients with systemic sclerosis.European heart journal. Imaging methods and practice · 2023Article
- Sex-Specific Differences in Left Ventricular Mass and Volumes with Body Mass Index among Children Aged 6 to 8: A Cross-Sectional Study in China.Nutrients · 2023Article
- The relationship between epicardial adipose tissue thickness and arrhythmias in patients with hypertension: a 3.0T cardiac magnetic resonance study.The British journal of radiology · 2023Article
- Tissue-growth-based synthetic tree generation and perfusion simulation.Biomechanics and modeling in mechanobiology · 2023Article
- Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition.JACC. Basic to translational science · 2023 · on this mapArticle
- Connecting epicardial adipose tissue and heart failure with preserved ejection fraction: mechanisms, management and modern perspectives.European journal of heart failure · 2022Review
- Epicardial Adipose Tissue Was Highly Associated with Reduction in Left Ventricular Diastolic Function as Early as in Adolescence.Acta Cardiologica Sinica · 2022Article
- Changes in Cardiac Metabolism in Prediabetes.Biomolecules · 2021Review
- Cardiac Adipose Tissue Contributes to Cardiac Repair: a Review.Stem cell reviews and reports · 2021Review
- The predictive value of epicardial adipose tissue volume assessed by cardiac magnetic resonance for atrial fibrillation in patients with hypertrophic obstructive cardiomyopathy.The international journal of cardiovascular imaging · 2021Observational
- Prognostic value of peripheral blood inflammatory cell subsets in patients with acute coronary syndrome undergoing percutaneous coronary intervention.The Journal of international medical research · 2021Article
- Association of pericardial adipose tissue with left ventricular structure and function: a region-specific effect?Cardiovascular diabetology · 2021Article
- Combined CT score, blood mononuclear cell count, LDH, and plasma D-dimer for viral pneumonia diagnosis: a retrospective study.International journal of clinical and experimental pathology · 2021Article
- Association of lymphocyte-to-monocyte ratio with total coronary plaque burden in patients with coronary artery disease.Coronary artery disease · 2020Article
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Authors and funding
12 authors.
Funding
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Abstract
purposeEpicardial adipose tissue (EAT) has been linked to coronary artery disease (CAD) and coronary microvascular dysfunction. However, its injurious effect may also impact the underlying myocardium. This study aimed to determine the impact of obesity on the quantitative relationship between left ventricular mass (LVM), EAT and coronary microvascular function.
methodsA total of 208 (94 men, 45 %) patients evaluated for CAD but free of coronary obstructions underwent quantitative [(15)O]H2O hybrid positron emission tomography (PET)/CT imaging. Coronary microvascular resistance (CMVR) was calculated as the ratio of mean arterial pressure to hyperaemic myocardial blood flow.
resultsObese patients [body mass index (BMI) > 25, n = 133, 64 % of total] had more EAT (125.3 ± 47.6 vs 93.5 ± 42.1 cc, p < 0.001), a higher LVM (130.1 ± 30.4 vs 114.2 ± 29.3 g, p < 0.001) and an increased CMVR (26.6 ± 9.1 vs 22.3 ± 8.6 mmHg×ml(-1)×min(-1)×g(-1), p < 0.01) as compared to nonobese patients. Male gender (β = 40.7, p < 0.001), BMI (β = 1.61, p < 0.001), smoking (β = 6.29, p = 0.03) and EAT volume (β = 0.10, p < 0.01) were identified as independent predictors of LVM. When grouped according to BMI status, EAT was only independently associated with LVM in nonobese patients. LVM, hypercholesterolaemia and coronary artery calcium score were independent predictors of CMVR.
conclusionEAT volume is associated with LVM independently of BMI and might therefore be a better predictor of cardiovascular risk than BMI. However, EAT volume was not related to coronary microvascular function after adjustments for LVM and traditional risk factors.
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