ArticleJournal of cell science2015
TORC2 mediates the heat stress response in Drosophila by promoting the formation of stress granules.
Article in Journal of cell science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 44 citations in OpenAlex.
- Stress granule dynamics govern TOR reactivation and growth recovery during post-heat stress adaptation.Science advances · 2025Article
- Precise andACS central science · 2025Article
- Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4.Theranostics · 2025Article
- Gene model for the ortholog ofmicroPublication biology · 2025Article
- Feeding a rich diet supplemented with the translation inhibitor cycloheximide decreases lifespan and ovary size in Drosophila.Biology open · 2024Article
- Feeding a rich diet supplemented with the translation inhibitor cycloheximide decreases lifespan and ovary size in Drosophila.bioRxiv : the preprint server for biology · 2024Article
- Heat tolerance inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Systemic changes in cell size throughout the body of Drosophila melanogaster associated with mutations in molecular cell cycle regulators.Scientific reports · 2023Article
- Article
- Role of gut commensal bacteria in juvenile developmental growth of the host: insights fromAnimal cells and systems · 2023Review
- The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023Article
- Review
- Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies.GeroScience · 2022Article
- Identification of the stress granule transcriptome via RNA-editing in single cells andCell reports methods · 2022Article
- Mechanism and effect of stress granule formation in cancer and its potential roles in breast cancer therapy.Genes & diseases · 2022Review
- Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis.Development (Cambridge, England) · 2022Article
- Detecting Stress Granules in Drosophila Neurons.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics.Molecular biology of the cell · 2021Article
- Stress granules inhibit fatty acid oxidation by modulating mitochondrial permeability.Cell reports · 2021Article
- Stress Granules Involved in Formation, Progression and Metastasis of Cancer: A Scoping Review.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinase TOR is found in two complexes, TORC1, which is involved in growth control, and TORC2, whose roles are less well defined. Here, we asked whether TORC2 has a role in sustaining cellular stress. We show that TORC2 inhibition in Drosophila melanogaster leads to a reduced tolerance to heat stress, whereas sensitivity to other stresses is not affected. Accordingly, we show that upon heat stress, both in the animal and Drosophila cultured S2 cells, TORC2 is activated and is required for maintaining the level of its known target, Akt1 (also known as PKB). We show that the phosphorylation of the stress-activated protein kinases is not modulated by TORC2 nor is the heat-induced upregulation of heat-shock proteins. Instead, we show, both in vivo and in cultured cells, that TORC2 is required for the assembly of heat-induced cytoprotective ribonucleoprotein particles, the pro-survival stress granules. These granules are formed in response to protein translation inhibition imposed by heat stress that appears to be less efficient in the absence of TORC2 function. We propose that TORC2 mediates heat resistance in Drosophila by promoting the cell autonomous formation of stress granules.
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