ReviewObesity (Silver Spring, Md.)2015
Shaping fat distribution: New insights into the molecular determinants of depot- and sex-dependent adipose biology.
Review in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of patient factors affecting adipose stem cell viability and function: implications for regenerative therapy.Stem cell research & therapy · 2017Pooled it
- CT Fat Density Accurately Reflects Histologic Fat Quality in Adults With HIV On and Off Antiretroviral Therapy.The Journal of clinical endocrinology and metabolism · 2019Trial
- Effect of flurbiprofen axetil on postoperative delirium for elderly patients.Brain and behavior · 2019Trial
- Differential open chromatin profile and transcriptomic signature define depot-specific human subcutaneous preadipocytes: primary outcomes.Clinical epigenetics · 2018Trial
- Sexual dimorphism in the development and function of the melanocortin system.Reviews in endocrine & metabolic disorders · 2026Review
- Advances in the Role of Adipose Tissue in Promoting Injury Repair and Resist Infection.Immunity, inflammation and disease · 2026Review
- "Pericoronary adipose tissue attenuation as a marker of global coronary inflammation rather than lesion-specific risk".Frontiers in cardiovascular medicine · 2026Article
- The Association Between Height-Related Novel Anthropometric Indices and Cardiovascular Events: A Cross-Sectional Insight From the MASHAD Cohort Study.Health science reports · 2026Article
- The association between retinal artery to vein ratio and fat distribution: a population-based cross-sectional study.BMC ophthalmology · 2025Article
- Association of Android and Gynoid Fatness With Incident Dementia and Brain Structure.Journal of cachexia, sarcopenia and muscle · 2025Article
- Sex Differences in Risk of Adverse Liver Events in Patients With Cirrhosis.JAMA network open · 2025Article
- Waist-to-Height Ratio, Waist Circumference, and Body Mass Index in Relation to Full Cardiometabolic Risk in an Adult Population from Medellin, Colombia.Journal of clinical medicine · 2025Article
- Investigating the impact of sex and reproductive aging on latent signatures of modifiable dementia risk factors.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Gender differences in the association between weight-adjusted waist index and migraine: A cross-sectional study.PloS one · 2025Article
- Impact of Subcutaneous Adipose Tissue Index Change During Neoadjuvant Chemoradiotherapy on Disease-Free Survival and Tumor Response in Patients with Locally Advanced Rectal Cancer.International journal of medical sciences · 2025Article
- A validated estimate of visceral adipose tissue volume in relation to cancer risk.Journal of the National Cancer Institute · 2024Article
- Sex- and gender-based medicine in pediatric nutrition.Italian journal of pediatrics · 2024Review
- FGF21 mediating the Sex-dependent Response to Dietary Macronutrients.The Journal of clinical endocrinology and metabolism · 2024Review
- FemaleInternational journal of molecular sciences · 2024Article
- Association between Variants of the TRPV1 Gene and Body Composition in Sub-Saharan Africans.Genes · 2024Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
objectiveTo review recent advances in understanding the cellular mechanisms that regulate fat distribution.
methodsIn this review, new insights into depot and sex differences in the developmental origins and growth of adipose tissues as revealed by studies that use new methods, including lineage tracing, are highlighted.
resultsVariations in fat distribution during normal growth and in response to alterations in nutritional or hormonal status are driven by intrinsic differences in cells found in each adipose depot. Adipose progenitor cells and preadipocytes in different anatomical adipose tissues derive from cell lineages that determine their capacity for proliferation and differentiation. As a result, rates of hypertrophy and hyperplasia during growth and remodeling vary among depots. The metabolic capacities of adipose cells are also determined by variations in the expression of key transcription factors and non-coding RNAs. These developmental events are influenced by sex chromosomes and hormonal and nutrient signals that determine the adipogenic, metabolic, and functional properties of each depot.
conclusionsThese new developments in the understanding of fat distribution provide a sound basis for understanding the association of body shape and health in men and women with and without obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.