ArticlePediatric nephrology (Berlin, Germany)2015
Long-term renal outcomes of childhood-onset global and segmental diffuse proliferative lupus nephritis.
Article in Pediatric nephrology (Berlin, Germany), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Management and outcomes in children with lupus nephritis in the developing countries.Pediatric nephrology (Berlin, Germany) · 2023Pooled it
- Hepcidin and arterial stiffness in children with systemic lupus erythematosus and lupus nephritis: A cross-sectional study.PloS one · 2019Trial
- Pathogenesis, Treatment Advances, and Renal Outcomes in Childhood-Onset Lupus Nephritis.Clinical pediatrics · 2026Review
- Using a multi-institutional pediatric learning health system to characterize induction therapy for incident lupus nephritis in children.Pediatric nephrology (Berlin, Germany) · 2026Article
- Clinical characteristics, disease flares, infections and their impact on kidney outcomes in pediatric lupus nephritis: A cohort study.Pediatric nephrology (Berlin, Germany) · 2025Article
- Osteoporotic vertebral compression fracture in patients with childhood-onset lupus nephritis: prevalence and risk factors.Archives of osteoporosis · 2025Article
- COVID-19 vaccine hesitancy among parents of children with systemic lupus erythematosus.Clinical and experimental pediatrics · 2025Article
- Potential involvement of circulating exosomal miRNA-146a in disease activity andLupus science & medicine · 2024Article
- International cohort of 382 children with lupus nephritis - presentation, treatment and outcome at 24 months.Pediatric nephrology (Berlin, Germany) · 2023Article
- Childhood-Onset Lupus Nephritis in the Childhood Arthritis and Rheumatology Research Alliance Registry: Short-Term Kidney Status and Variation in Care.Arthritis care & research · 2023Article
- Chronic kidney disease in patients with childhood-onset systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Endocapillary hypercellularity levels are associated with early complete remission in children with class IV lupus nephritis as the initial presentation of SLE.BMC nephrology · 2022Article
- Differences in rituximab use between pediatric rheumatologists and nephrologists for the treatment of refractory lupus nephritis and renal flare in childhood-onset SLE.Pediatric rheumatology online journal · 2021Article
- Longitudinal growth patterns and final height in childhood-onset systemic lupus erythematosus.European journal of pediatrics · 2021Article
- Twelve-month outcome in juvenile proliferative lupus nephritis: results of the German registry study.Pediatric nephrology (Berlin, Germany) · 2020Article
- Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity.Rheumatology (Oxford, England) · 2019Article
- Urine S100 proteins as potential biomarkers of lupus nephritis activity.Arthritis research & therapy · 2017Article
- Measuring hemoglobin prior to early discharge without routine surveillance ultrasound after percutaneous native renal biopsy in children.Pediatric nephrology (Berlin, Germany) · 2017Article
- Urine Biomarkers to Predict Response to Lupus Nephritis Therapy in Children and Young Adults.The Journal of rheumatology · 2017Article
- Advances in the care of children with lupus nephritis.Pediatric research · 2017Review
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2 authors at 1 institution in 1 country.
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Abstract
backgroundData on global (IV-G) and segmental (IV-S) diffuse proliferative lupus nephritis (DPLN) in children are lacking.
methodsTo determine the clinicopathology and prognosis of DPLN subclasses IV-G and IV-S, we analyzed the clinical, laboratory, and demographic data of 56 children aged <18 years diagnosed with DPLN [36 (64.3%) with IV-G; 20 (35.7%) with IV-S] between 2004 and 2013. Clinical endpoints were: (1) complete remission (CR), (2) chronic kidney disease [CKD; defined as estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m(2) or end-stage renal disease (ESRD)], and (3) death.
resultsProteinuria and the activity index were higher in patients with IV-G (p < 0.05). Global endocapillary proliferation and leukocyte exudation were predominant in IV-G patients, whereas segmental endocapillary proliferation was predominant in patients with IV-S (p < 0.005). CR rates in IV-G and IV-S patients were 50 and 60%, respectively (p = 0.47). Renal survival rates, defined as an eGFR of ≥60 mL/min/1.73 m(2), were 93, 78, and 64% at 1, 5, and 10 years, respectively. Patient survival rates at 1, 5, and 10 years were 98, 96, and 91%, respectively. Patient and renal survival rates were similar in both subclasses.
conclusionsAlthough patients with IV-G and IV-S displayed some clinical and histopathological disparities, renal outcomes were similar. The majority of children with DPLN reached adulthood but accrued significant renal damage. Treatment regimens which can slow the progression of CKD are needed.
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