ArticleThe Journal of membrane biology2015
Molecular Simulation of Cell Membrane Deformation by Picosecond Intense Electric Pulse.
Article in The Journal of membrane biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Pulse width and intensity effects of pulsed electric fields on cancerous and normal skin cells.Scientific reports · 2022Article
- Mechanisms underlying interactions between PAMAM dendron-grafted surfaces with DPPC membranes.RSC advances · 2018Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of pulsed electric field is emerging as a new technique for cancer therapy. The irreversible electroporation is the major bioelectric effect to induce cell death. The pulsed electric field is transferred to target deep tissue non-invasively and precisely when the pulse duration is in picosecond regime. In this proposed work, the intense electric field with 100 ps pulse width is used for irreversible electroporation. If the electric field strength increases, the pore in the cell membrane enlarges, causing a loss of membrane intactness and the direct killing of cancer cells. This phenomenon is explored by molecular dynamics simulation. The electric field in the range of 0.8-5 V/nm is used for membrane dynamics. The membrane deformation occurs at the electric field of 5 V/nm. Picosecond pulsed electric field has a wealth of ultra-band spectrum, with extended time and enhanced spatial resolution and low signal distortion. The ultra-wide band antenna is used as a pulse delivery system for non-invasive skin cancer therapy.
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