Evidence map›Paper›PMID 26054049›Full record

Trial reportObesity (Silver Spring, Md.)2015

Effect of reducing portion size at a compulsory meal on later energy intake, gut hormones, and appetite in overweight adults.

Hannah B Lewis, Amy L Ahern, Ivonne Solis-Trapala, Celia G Walker, Frank Reimann, Fiona M Gribble, Susan A Jebb

Open access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Discordance between gut-derived appetite hormones and energy intake in humans.medRxiv : the preprint server for health sciences · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Observational
  17. Article
  18. Understanding the science of portion control and the art of downsizing.The Proceedings of the Nutrition Society · 2018
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hannah B LewisDiet and Obesity Research, Medical Research Council Human Nutrition Research, Cambridge, UK.
Amy L AhernDiet and Obesity Research, Medical Research Council Human Nutrition Research, Cambridge, UK.
Ivonne Solis-TrapalaDiet and Obesity Research, Medical Research Council Human Nutrition Research, Cambridge, UK.
Celia G WalkerDiet and Obesity Research, Medical Research Council Human Nutrition Research, Cambridge, UK.
Frank ReimannDepartment of Clinical Biochemistry, Institute of Metabolic Science, University of Cambridge, UK.
Fiona M GribbleDepartment of Clinical Biochemistry, Institute of Metabolic Science, University of Cambridge, UK.
Susan A JebbDiet and Obesity Research, Medical Research Council Human Nutrition Research, Cambridge, UK.
MRC Human Nutrition Research · GBUniversity of Cambridge · GBMedical Research Council · GB

Funding

Medical Research Council MC_U105960389Medical Research Council MC_UU_12012/3Medical Research Council MC_UU_12012/5Medical Research Council U105960389Wellcome Trust 088357
6 · The paper itself

Abstract

objectiveLarger portion sizes (PS) are associated with greater energy intake (EI), but little evidence exists on the appetitive effects of PS reduction. This study investigated the impact of reducing breakfast PS on subsequent EI, postprandial gastrointestinal hormone responses, and appetite ratings.

methodsIn a randomized crossover design (n = 33 adults; mean BMI 29 kg/m(2) ), a compulsory breakfast was based on 25% of gender-specific estimated daily energy requirements; PS was reduced by 20% and 40%. EI was measured at an ad libitum lunch (240 min) and snack (360 min) and by weighed diet diaries until bed. Blood was sampled until lunch in 20 participants. Appetite ratings were measured using visual analogue scales.

resultsEI at lunch (control: 2,930 ± 203; 20% reduction: 2,853 ± 198; 40% reduction: 2,911 ± 179 kJ) and over the whole day except breakfast (control: 7,374 ± 361; 20% reduction: 7,566 ± 468; 40% reduction: 7,413 ± 417 kJ) did not differ. Postprandial PYY, GLP-1, GIP, insulin, and fullness profiles were lower and hunger, desire to eat, and prospective consumption higher following 40% reduction compared to control. Appetite ratings profiles, but not hormone concentrations, were associated with subsequent EI.

conclusionsSmaller portions at breakfast led to reductions in gastrointestinal hormone secretion but did not affect subsequent energy intake, suggesting small reductions in portion size may be a useful strategy to constrain EI.

Indexed as

MealsPortion SizeAdolescentAdultAppetiteCross-Over StudiesDietEnergy IntakeFemaleGastric Inhibitory PolypeptideGastrointestinal HormonesGlucagon-Like Peptide 1HumansHungerInsulinMaleGastric Inhibitory PolypeptideGastrointestinal HormonesGlucagon-Like Peptide 1InsulinPeptide YY

Identifiers

PMID26054049
PMCPMC7212075
OpenAlexW1730992461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.