ArticleObesity (Silver Spring, Md.)2015
Changes in testosterone related to body composition in late midlife: Findings from the 1946 British birth cohort study.
Article in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Are we close to defining a metabolomic signature of human obesity? A systematic review of metabolomics studies.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- The Change in the Percent of Android and Gynoid Fat Mass Correlated with Increased Testosterone After Laparoscopic Sleeve Gastrectomy in Chinese Obese Men: a 6-Month Follow-Up.Obesity surgery · 2018Trial
- Role of Sex Hormones in Mediating Adiposity Changes From Weight Loss in People With Type 2 Diabetes: Look AHEAD Sex Hormone Study.The Journal of clinical endocrinology and metabolism · 2025Article
- Associations Between Female Sex Hormones and Skeletal Muscle Ageing: The Baltimore Longitudinal Study of Aging.Journal of cachexia, sarcopenia and muscle · 2025Article
- Observational
- The influence of body composition on the response to dynamic stimulation of the endocrine pituitary-testis axis.International journal of obesity (2005) · 2024Article
- Clinical Blood Metabogram: Application to Overweight and Obese Patients.Metabolites · 2023Article
- Using human genetics to understand the disease impacts of testosterone in men and women.Nature medicine · 2020Article
- Independent Impact of Gynoid Fat Distribution and Free Testosterone on Circulating Levels of N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) in Humans.Journal of clinical medicine · 2019Article
- Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years.Journal of the American Heart Association · 2018Article
- Plasma steroids, body composition, and fat distribution: effects of age, sex, and exercise training.International journal of obesity (2005) · 2018Article
- Socioeconomic conditions across life related to multiple measures of the endocrine system in older adults: Longitudinal findings from a British birth cohort study.Social science & medicine (1982) · 2015Article
- The complex and multifactorial relationship between testosterone deficiency (TD), obesity and vascular disease.Reviews in endocrine & metabolic disorders · 2015Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveRandomized trials in men with testosterone deficiency have provided evidence of short-term effects of testosterone therapy on muscle and fat mass but it is unclear whether this persists over a longer period or how testosterone affects women. We examined whether the midlife decline in testosterone relates to fat and lean mass in both sexes.
methodsData were collected from 440 men and 560 women participating in the 1946 British birth cohort study with testosterone measured at 53 and/or 60-64 years. Fat and appendicular lean mass were measured at 60-64 years using dual-energy X-ray absorptiometry.
resultsMean free testosterone concentrations were lower at 60-64 than 53 years, by 26% in both sexes. At both ages testosterone was negatively associated with fat mass in men and positively associated in women. A larger decline in free testosterone was associated with higher fat mass in men but with lower fat mass among women. In contrast, declines in testosterone were not associated with lean mass in either sex.
conclusionsOur findings suggest sex-divergent relationships between testosterone and fat mass and their distribution but do not support the hypothesis that midlife declines in testosterone lead to lower lean mass.
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