ArticleNano letters2015
General Strategy to Introduce pH-Induced Allostery in DNA-Based Receptors to Achieve Controlled Release of Ligands.
Article in Nano letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- NIR-switched DNA tweezer enables reversible miRNA recognition with erasable signal for in vivo continuous imaging.Science advances · 2026Article
- Advancing precision medicine with bioelectroanalytical technologies leveraging unconventional nucleic acid forms.Analytical and bioanalytical chemistry · 2026Review
- pH-responsive synthetic cells for controlled protein synthesis and release.bioRxiv : the preprint server for biology · 2025Article
- DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes.Nature communications · 2025Article
- In Situ Electrically Resettable Field-Effect Transistor Biosensors for Continuous and Multiplexed Neurotransmitter Detection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Oriented triplex DNA as a synthetic receptor for transmembrane signal transduction.Nature communications · 2024Article
- Controlling DNA nanodevices with light-switchable buffers.Chemical communications (Cambridge, England) · 2023Article
- Thermo-Programmed Synthetic DNA-Based Receptors.ACS nano · 2023Article
- Three's a crowd - stabilisation, structure, and applications of DNA triplexes.Chemical science · 2022Review
- Dissipative DNA nanotechnology.Nature chemistry · 2022Review
- Combining Electrochemiluminescence Detection with Aptamer-Gated Indicator Releasing Mesoporous Nanoparticles Enables ppt Sensitivity for Strip-Based Rapid Tests.Angewandte Chemie (International ed. in English) · 2021Article
- Dissipative operation of pH-responsive DNA-based nanodevices.Chemical science · 2021Article
- DNA Assembly-Based Stimuli-Responsive Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Review
- Proton gradients from light-harvesting E. coli control DNA assemblies for synthetic cells.Nature communications · 2021Article
- A unified computational view of DNA duplex, triplex, quadruplex and their donor-acceptor interactions.Nucleic acids research · 2021Article
- Flexible Multiplexed IniScience · 2020Article
- A photo zipper locked DNA nanomachine with an internal standard for precise miRNA imaging in living cells.Chemical science · 2020Article
- 5-Carboxylcytosine and Cytosine Protonation Distinctly Alter the Stability and Dehybridization Dynamics of the DNA Duplex.The journal of physical chemistry. B · 2020Article
- Programmable Bivalent Peptide-DNA Locks for pH-Based Control of Antibody Activity.ACS central science · 2020Article
- Direct Selection Strategy for Isolating Aptamers with pH-Sensitive Binding Activity.ACS sensors · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired by naturally occurring pH-regulated receptors, here we propose a rational approach to introduce pH-induced allostery into a wide range of DNA-based receptors. To demonstrate this we re-engineered two model DNA-based probes, a molecular beacon and a cocaine-binding aptamer, by introducing in their sequence a pH-dependent domain. We demonstrate here that we can finely tune the affinity of these model receptors and control the load/release of their specific target molecule by a simple pH change.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.