ArticleThe Journal of comparative neurology2016
Bilateral lesions in a specific subregion of posterior insular cortex impair conditioned taste aversion expression in rats.
Article in The Journal of comparative neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 34 citations in OpenAlex.
- Comparative insights into insula structure and function.Nature neuroscience · 2026Review
- Cortical coding of gustatory and thermal signals in active licking mice.The Journal of physiology · 2025Article
- Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice.bioRxiv : the preprint server for biology · 2024Article
- Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.Alcohol, clinical & experimental research · 2024Article
- Does insular cortex lesion cause tinnitus in rats?Iranian journal of basic medical sciences · 2022Article
- Better living through understanding the insula: Why subregions can make all the difference.Neuropharmacology · 2021Review
- Top-down control of conditioned overconsumption is mediated by insular cortex Nos1 neurons.Cell metabolism · 2021Article
- Chemospecific deficits in taste sensitivity following bilateral or right hemispheric gustatory cortex lesions in rats.The Journal of comparative neurology · 2020Article
- Experience Informs Consummatory Choices for Congruent and Incongruent Odor-Taste Mixtures in Rats.Chemical senses · 2020Article
- Taste coding strategies in insular cortex.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Assessing Reality Testing in Mice Through Dopamine-Dependent Associatively Evoked Processing of Absent Gustatory Stimuli.Schizophrenia bulletin · 2020Article
- Recognizing Taste: Coding Patterns Along the Neural Axis in Mammals.Chemical senses · 2019Review
- The Functional and Neurobiological Properties of Bad Taste.Physiological reviews · 2019Review
- Nicotine pre-treatment reduces sensitivity to the interoceptive stimulus effects of commonly abused drugs as assessed with taste conditioning paradigms.Drug and alcohol dependence · 2019Article
- Transcriptomic Characterization of the Human Insular Cortex and Claustrum.Frontiers in neuroanatomy · 2019Article
- Experience-dependent c-Fos expression in the primary chemosensory cortices of the rat.Brain research · 2018Article
- The role of the gustatory cortex in incidental experience-evoked enhancement of later taste learning.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Distribution of Fos-immunoreactive neurons in the gustatory cortex elicited by intra-oral infusion of taste solutions in conscious rats.Brain research · 2018Article
- Opioid and orexin hedonic hotspots in rat orbitofrontal cortex and insula.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Overlapping Representation of Primary Tastes in a Defined Region of the Gustatory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gustatory cortex (GC) is widely regarded for its integral role in the acquisition and retention of conditioned taste aversions (CTAs) in rodents, but large lesions in this area do not always result in CTA impairment. Recently, using a new lesion mapping system, we found that severe CTA expression deficits were associated with damage to a critical zone that included the posterior half of GC in addition to the insular cortex (IC) that is just dorsal and caudal to this region (visceral cortex). Lesions in anterior GC were without effect. Here, neurotoxic bilateral lesions were placed in the anterior half of this critical damage zone, at the confluence of the posterior GC and the anterior visceral cortex (termed IC2 ), the posterior half of this critical damage zone that contains just VC (termed IC3), or both of these subregions (IC2 + IC3). Then, pre- and postsurgically acquired CTAs (to 0.1 M NaCl and 0.1 M sucrose, respectively) were assessed postsurgically in 15-minute one-bottle and 96-hour two-bottle tests. Li-injected rats with histologically confirmed bilateral lesions in IC2 exhibited the most severe CTA deficits, whereas those with bilateral lesions in IC3 were relatively normal, exhibiting transient disruptions in the one-bottle sessions. Groupwise lesion maps showed that CTA-impaired rats had more extensive damage to IC2 than did unimpaired rats. Some individual differences in CTA expression among rats with similar lesion profiles were observed, suggesting idiosyncrasies in the topographic representation of information in the IC. Nevertheless, this study implicates IC2 as the critical zone of the IC for normal CTA expression.
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