ArticlePloS one2015
Increased Risk of Depressive Disorder following Cholecystectomy for Gallstones.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Adult Post-operative Mental Health Outcomes Following Abdominal and Orthopedic Surgeries: A Scoping Review.Cureus · 2026Review
- Association of cholecystectomy with short-term and long-term risks of depression and suicide.Scientific reports · 2025Article
- Bridging Three Years of Insights: Examining the Association Between Depression and Gallstone Disease.Journal of clinical medicine research · 2024Article
- Depression and hepatobiliary diseases: a bidirectional Mendelian randomization study.Frontiers in psychiatry · 2024Article
- New onset postoperative depression after major surgery: an analysis from a national claims database.BJA open · 2023Article
- Are laparoscopic cholecystectomy and natural orifice transluminal endoscopic surgery gallbladder preserving cholecystolithotomy truly comparable? A propensity matched study.World journal of gastrointestinal surgery · 2022Article
- Patients receiving androgen deprivation therapy for prostate cancer have an increased risk of depressive disorder.PloS one · 2017Article
- Depression After Spinal Surgery: A Comparative Analysis of the California Outcomes Database.Mayo Clinic proceedings · 2017Article
- Review of imaging in post-laparoscopy cholecystectomy complications.The Indian journal of radiology & imagingArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrior studies indicate a possible association between depression and cholecystectomy, but no study has compared the risk of post-operative depressive disorders (DD) after cholecystectomy. This retrospective follow-up study aimed to examine the relationship between cholecystectomy and the risk of DD in patients with gallstones in a population-based database.
methodsUsing ambulatory care data from the Longitudinal Health Insurance Database 2000, 6755 patients who received a first-time principal diagnosis of gallstones at the emergency room (ER) were identified. Among them, 1197 underwent cholecystectomy. Each patient was then individually followed-up for two years to identify those who were later diagnosed with DD. Cox proportional hazards regressions were performed to estimate the risk of developing DD between patients with gallstone who did and those who did not undergo cholecystectomy.
resultsOf 6755 patients with gallstones, 173 (2.56%) were diagnosed with DD during the two-year follow-up. Among patients who did and those who did not undergo cholecystectomy, 3.51% and 2.36% later developed depressive disorder, respectively. After adjusting for the patient's sex, age and geographic location, the hazard ratio (HR) of DD within two years of gallstone diagnosis was 1.43 (95% CI, 1.02-2.04) for patients who underwent cholecystectomy compared to those who did not. Females, but not males, had a higher the adjusted HR of DD (1.61; 95% CI, 1.08-2.41) for patients who underwent cholecystectomy compared to those who did not.
conclusionsThere is an association between cholecystectomy and subsequent risk of DD among females, but not in males.
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