Evidence map›Paper›PMID 26053868›Full record

ArticleACS nano2015

Detoxification of Organophosphate Poisoning Using Nanoparticle Bioscavengers.

Zhiqing Pang, Che-Ming J Hu, Ronnie H Fang, Brian T Luk, Weiwei Gao, Fei Wang, Erdembileg Chuluun, Pavimol Angsantikul, Soracha Thamphiwatana, Weiyue Lu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 154 citations in OpenAlex.

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  16. Erythrocyte-Inspired Functional Materials for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Zhiqing Pang†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Che-Ming J Hu†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Ronnie H Fang†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Brian T Luk†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Weiwei Gao†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Fei Wang†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Erdembileg Chuluun†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Pavimol Angsantikul†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Soracha Thamphiwatana†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
Weiyue Lu‡Department of Pharmaceutics, School of Pharmacy, Fudan University, and Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, People's Republic of China.
Xinguo Jiang‡Department of Pharmaceutics, School of Pharmacy, Fudan University, and Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education, Shanghai 201203, People's Republic of China.
Liangfang Zhang†Department of NanoEngineering and Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, United States.
University of California, San Diego · USFudan University · CN

Funding

Innate Antimicrobial Nanotherapeutics for the Treatment of H. pylori InfectionR01DK095168 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZHANG, LIANGFANG · 2012 to 2016
$1.6M
NIDDK NIH HHS R01 DK095168NIDDK NIH HHS R01DK095168
6 · The paper itself

Abstract

Organophosphate poisoning is highly lethal as organophosphates, which are commonly found in insecticides and nerve agents, cause irreversible phosphorylation and inactivation of acetylcholinesterase (AChE), leading to neuromuscular disorders via accumulation of acetylcholine in the body. Direct interception of organophosphates in the systemic circulation thus provides a desirable strategy in treatment of the condition. Inspired by the presence of AChE on red blood cell (RBC) membranes, we explored a biomimetic nanoparticle consisting of a polymeric core surrounded by RBC membranes to serve as an anti-organophosphate agent. Through in vitro studies, we demonstrated that the biomimetic nanoparticles retain the enzymatic activity of membrane-bound AChE and are able to bind to a model organophosphate, dichlorvos, precluding its inhibitory effect on other enzymatic substrates. In a mouse model of organophosphate poisoning, the nanoparticles were shown to improve the AChE activity in the blood and markedly improved the survival of dichlorvos-challenged mice.

Indexed as

AcetylcholinesteraseAnimalsBiomimetic MaterialsDichlorvosDisease Models, AnimalErythrocytesMaleMiceMice, Inbred StrainsNanoparticlesOrganophosphate PoisoningAcetylcholinesteraseDichlorvosacetylcholinesterasebiodetoxificationbiomimetic nanoparticlenanomedicineorganophosphate

Identifiers

PMID26053868
PMCPMC4832962
OpenAlexW634813441

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.