Runx1 and Runx3 Are Downstream Effectors of Nanog in Promoting Osteogenic Differentiation of the Mouse Mesenchymal Cell Line C3H10T1/2.

Tadahito Saito, Shinsuke Ohba, Fumiko Yano, Ichiro Seto, Yoshiyuki Yonehara, Tsuyoshi Takato, Toru Ogasawara

Open access · greenAbstract read

In one paragraph

Article in Cellular reprogramming, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it

0cells of the map it votes in

4citing papers in PubMed

0.3field-weighted citation impact, top 39% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025.Osteoarthritis and cartilage open · 2026
Article
RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway.Regenerative therapy · 2021
Article
Mechanisms of miR‑128‑3p in inhibiting osteoblast differentiation from bone marrow‑derived mesenchymal stromal cells.Molecular medicine reports · 2020
Article
Identification of key transcription factors - gene regulatory network related with osteogenic differentiation of human mesenchymal stem cells based on transcription factor prognosis system.Experimental and therapeutic medicine · 2019
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tadahito Saito1 Department of Oral and Maxillofacial Surgery, The University of Tokyo , Tokyo 113-8655, Japan .

Shinsuke Ohba2 Department of Bioengineering, Graduate School of Engineering, The University of Tokyo , Tokyo 113-8655, Japan .

Fumiko Yano1 Department of Oral and Maxillofacial Surgery, The University of Tokyo , Tokyo 113-8655, Japan .

Ichiro Seto1 Department of Oral and Maxillofacial Surgery, The University of Tokyo , Tokyo 113-8655, Japan .

Yoshiyuki Yonehara3 Nihon University School of Dentistry , Department of Oral and Maxillofacial Surgery, Tokyo 101-8310, Japan .

Tsuyoshi Takato1 Department of Oral and Maxillofacial Surgery, The University of Tokyo , Tokyo 113-8655, Japan .

Toru Ogasawara1 Department of Oral and Maxillofacial Surgery, The University of Tokyo , Tokyo 113-8655, Japan .

University of Tokyo Hospital · JPNihon University · JPThe University of Tokyo · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, we reported that the transcription factor Nanog, which maintains the self-renewal of embryonic stem cells (ESCs), promotes the osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 through a genome reprogramming process. In the present study, to clarify the mechanism underlying the multipotency of mesenchymal stem cells (MSCs) and to develop a novel approach to bone regenerative medicine, we attempted to identify the downstream effectors of Nanog in promoting osteogenic differentiation of mouse mesenchymal cells. We demonstrated that Runx1 and Runx3 are the downstream effectors of Nanog, especially in the early and intermediate osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2.

Indexed as

OsteogenesisAnimalsCell LineCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitHomeodomain ProteinsMesenchymal Stem CellsMiceNanog Homeobox ProteinSignal TransductionCore Binding Factor Alpha 2 SubunitCore Binding Factor Alpha 3 SubunitHomeodomain ProteinsNanog Homeobox ProteinNanog protein, mouseRunx1 protein, mouseRunx3 protein, mouse

Identifiers

PMID26053522

DOI10.1089/cell.2014.0059

PMCPMC4487263

OpenAlexW1632524712

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.