ArticlePloS one2015
Adherence with Dosing Guideline in Patients with Impaired Renal Function at Hospital Discharge.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Barriers and facilitators to the implementation of guidelines in rare diseases: a systematic review.Orphanet journal of rare diseases · 2023Pooled it
- Juvenile Inflammatory Rheumatism Real-Life Clinical Practice Strategies (JIR-CliPS) network: methodology and the development process.Orphanet journal of rare diseases · 2026Article
- Poor performance of ChatGPT in clinical rule-guided dose interventions in hospitalized patients with renal dysfunction.European journal of clinical pharmacology · 2024Article
- Navigating nephrology: unveiling pharmacist perspectives on renal dose adjustment in Saudi Arabia - a comprehensive cross-sectional analysis.Journal of pharmaceutical policy and practice · 2024Article
- Knowledge, attitude and perceptions of pharmacists regarding renal dose adjustment among chronic kidney disease patients in Pakistan.Journal of pharmaceutical policy and practice · 2023Article
- Article
- Prevalence of inappropriate drug dose adjustment and associated factors among inpatients with renal impairment in Africa: A systematic review and meta-analysis.SAGE open medicine · 2023Review
- Development of a Theory-Informed Behavior Change Intervention to Reduce Inappropriate Prescribing of Nephrotoxins and Renally Eliminated Drugs.The Annals of pharmacotherapy · 2021Article
- Assessment of Medication Dosage Adjustment in Hospitalized Patients With Chronic Kidney Disease.Cureus · 2021Article
- Quality assessment and cost saving of renal dosing recommendation by clinical pharmacists at medical wards in Thailand.International journal of clinical pharmacy · 2020Article
- Medical Students' and Internal Medicine Trainees' Knowledge of Drug Prescribing Recommendations in Older Patients with Impaired Kidney Function.Clinical interventions in aging · 2020Article
- Effectiveness of adherence to a renal health program in a health network in Peru.Revista de saude publica · 2020Article
- The effect of hospital-based antithrombotic stewardship on adherence to anticoagulant guidelines.International journal of clinical pharmacy · 2019Article
- Impact of pharmacists' interventions on physicians' decision of a knowledge-based renal dosage adjustment system.International journal of clinical pharmacy · 2019Article
- Use of renal risk drugs in a nation-wide Polish older adult population: an analysis of PolSenior database.BMC geriatrics · 2019Article
- Article
- Article
- Management Practice, and Adherence and Its Contributing Factors among Patients with Chronic Kidney Disease at Tikur Anbessa Specialized Hospital: A Hospital Based Cross-Sectional Study.International journal of nephrology · 2018Article
- A multifaceted intervention to reduce guideline non-adherence among prescribing physicians in Dutch hospitals.International journal of clinical pharmacy · 2017Article
- Phase I trial to investigate the effect of renal impairment on isavuconazole pharmacokinetics.European journal of clinical pharmacology · 2017Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine the prevalence, determinants, and potential clinical relevance of adherence with the Dutch dosing guideline in patients with impaired renal function at hospital discharge.
designRetrospective cohort study between January 2007 and July 2011.
settingAcademic teaching hospital in the Netherlands. SUBJECTS: Patients with an estimated glomerular filtration rate (eGFR) between 10-50 ml/min/1.73 m(2) at discharge and prescribed one or more medicines of which the dose is renal function dependent.
main outcome measuresThe prevalence of adherence with the Dutch renal dosing guideline was investigated, and the influence of possible determinants, such as reporting the eGFR and severity of renal impairment (severe: eGFR<30 and moderate: eGFR 30-50 ml/min/1.73 m(2)). Furthermore, the potential clinical relevance of non-adherence was assessed.
results1327 patients were included, mean age 67 years, mean eGFR 38 ml/min/1.73 m(2). Adherence with the guideline was present in 53.9% (n=715) of patients. Reporting the eGFR, which was incorporated since April 2009, resulted in more adherence with the guideline: 50.7% vs. 57.0%, RR 1.12 (95% CI 1.02-1.25). Adherence was less in patients with severe renal impairment (46.0%), compared to patients with moderate renal impairment (58.1%, RR 0.79; 95% CI 0.70-0.89). 71.4% of the cases of non-adherence had the potential to cause moderate to severe harm.
conclusionRequired dosage adjustments in case of impaired renal function are often not performed at hospital discharge, which may cause harm to the majority of patients. Reporting the eGFR can be a small and simple first step to improve adherence with dosing guidelines.
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