Evidence map›Paper›PMID 26053330›Full record

ArticleScientific reports2015

Biomimetic Intrafibrillar Mineralization of Type I Collagen with Intermediate Precursors-loaded Mesoporous Carriers.

Wei Zhang, Xiao-juan Luo, Li-na Niu, Hong-ye Yang, Cynthia K Y Yiu, Tian-da Wang, Li-qun Zhou, Jing Mao, Cui Huang, David H Pashley and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Collagens of Poriferan Origin.Marine drugs · 2018
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei ZhangTongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
Xiao-juan LuoTongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
Li-na NiuState Key Laboratory of Military Stomatology, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, PR China.
Hong-ye YangWuhan University, Wuhan, PR China.
Cynthia K Y YiuUniversity of Hong Kong, Hong Kong SAR, PR China.
Tian-da WangPeking University School and Hospital of Stomatology, Beijing, PR China.
Li-qun ZhouWuhan University, Wuhan, PR China.
Jing MaoTongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China.
Cui HuangWuhan University, Wuhan, PR China.
David H PashleyGeorgia Regents University, Augusta, Georgia, 30912-1129, USA.
Franklin R TayGeorgia Regents University, Augusta, Georgia, 30912-1129, USA.

Funding

Reasons for poor durability of resin-dentin bondsR01DE015306 · NIDCR · MEDICAL COLLEGE OF GEORGIA (MCG) · PI PASHLEY, DAVID H · 2004 to 2013
$4.4M
Withdrawal-Stress, Anxiety, and Amygdala NeurophysiologyU01AA020942 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCOOL, BRIAN A · 2012 to 2016
$911k
NIAAA NIH HHS U01 AA020942NIDCR NIH HHS R01 DE015306NIDCR NIH HHS R01 DE015306-06
6 · The paper itself

Abstract

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

Indexed as

AnimalsBiomimetic MaterialsBiomimeticsBone and BonesCalcium PhosphatesCells, CulturedCollagen Type ICrystallizationDelayed-Action PreparationsDrug CarriersNanoparticlesRatsRats, WistarSilicon DioxideTooth Remineralizationamorphous calcium phosphateCalcium PhosphatesCollagen Type IDelayed-Action PreparationsDrug CarriersSilicon Dioxide

Identifiers

PMID26053330
PMCPMC4459175

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.