ArticleExperimental and clinical psychopharmacology2015
Application of an alcohol clamp paradigm to examine inhibitory control, subjective responses, and acute tolerance in late adolescence.
Article in Experimental and clinical psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Poor inhibitory control is associated with greater stimulation and less sedation following alcohol.Psychopharmacology · 2020Trial
- Relationships between generalized impulsivity and subjective stimulant and sedative responses following alcohol administration.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019Trial
- Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis.Alcoholism, clinical and experimental research · 2016Trial
- College Students' ADHD Symptoms and Alcohol Response During Laboratory Self-Administration.European journal of investigation in health, psychology and education · 2026Article
- Disentangling between- and within-person alcohol and expectancy effects on acute alcohol craving.Psychopharmacology · 2023Article
- Heightened motor impairment as a protective factor against heavy drinking in individuals with high alcohol-induced disinhibition.Alcohol, clinical & experimental research · 2023Article
- Sensitivity to the disinhibiting effect of alcohol: The role of trait impulsivity and sex differences.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022Article
- Pharmacodynamic determinants of hangover: An intravenous alcohol self-administration study in non-dependent drinkers.Addictive behaviors · 2022Article
- Developing a Smoking Cessation Intervention for People With Severe Mental Illness Treated by Flexible Assertive Community Treatment Teams in the Netherlands: A Delphi Study.Frontiers in psychiatry · 2022Article
- Subjective alcohol responses in high- and low-risk adolescents: results from the Dresden Longitudinal Study on Alcohol Use in Young Adults.Addiction (Abingdon, England) · 2021Article
- Relations Between Acute Effects of Alcohol on Response Inhibition, Impaired Control over Alcohol Use, and Alcohol-Related Problems.Alcoholism, clinical and experimental research · 2020Article
- To Infuse or Ingest in Human Laboratory Alcohol Research.Alcoholism, clinical and experimental research · 2020Review
- Suggestibility is associated with alcohol self-administration, subjective alcohol effects, and self-reported drinking behavior.Journal of psychopharmacology (Oxford, England) · 2019Article
- A Review of Developmental Considerations in Human Laboratory Alcohol Research.Current addiction reports · 2017Article
- A prospective study of genetic factors, human laboratory phenotypes, and heavy drinking in late adolescence.Addiction biology · 2017Article
- Craving and acute effects of alcohol in youths' daily lives: Associations with alcohol use disorder severity.Experimental and clinical psychopharmacology · 2017Article
- Association between overall rate of change in rising breath alcohol concentration and the magnitude of acute tolerance of subjective intoxication via the Mellanby method.Human psychopharmacology · 2017Article
- Multisensory Stop Signals Can Reduce the Disinhibiting Effects of Alcohol in Adults.Alcoholism, clinical and experimental research · 2016Article
- A multilevel structural equation model of within- and between-person associations among subjective responses to alcohol, craving, and laboratory alcohol self-administration.Journal of abnormal psychology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Individual differences in acute alcohol effects on cognitive control and subjective responses--and acute tolerance to these effects--are implicated in the risk for heavy drinking and alcohol-related harms. Few studies have examined these effects in drinkers under age 21. Additionally, studies of acute tolerance typically involve bolus oral alcohol administration, such that estimates of tolerance are confounded with blood alcohol concentration (BAC) limb. The current study examined cognitive control and subjective responses in young heavy drinkers (n = 88; M = 19.8 years old, SD = 0.8) during a single-session alcohol clamp protocol. Participants completed an intravenous alcohol session comprising an ascending limb (0 to 80 mg% in 20 min) and a BAC plateau (80 mg% for 80 min). Serial assessments included a cued go/no-go task and measures of stimulation, sedation, and craving. Relevant individual difference factors (attention-deficit hyperactivity disorder [ADHD] symptoms and sensation seeking) were examined as moderators. Multilevel modeling demonstrated that response inhibition worsened following initial rise in BAC and showed increasing impairment during the BAC plateau. ADHD symptoms and sensation seeking moderated this effect. Significant within-person associations between stimulation and craving were evident on the ascending limb only. Participants with higher ADHD symptoms reported steeper increases in stimulation during the ascending limb. These findings provide initial information about subjective and behavioral responses during pseudoconstant BAC, and potential moderators of these outcomes, in late adolescence. Additional studies with placebo-controlled designs are necessary to confirm these findings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.