ArticleAnnals of the American Thoracic Society2015
Pulmonary Gas Exchange and Exercise Capacity in Adults Born Preterm.
Article in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005289 (Risk Factors in Bronchopulmonary Dysplasia), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Risk Factors in Bronchopulmonary Dysplasia (Newborn Lung Project)
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Influence of Preterm Birth and Low Birthweight on Physical Fitness: A Systematic Review, Meta-Analysis, and Meta-Regression.Sports medicine (Auckland, N.Z.) · 2024Pooled it
- The Effect of Preterm Birth on Maximal Aerobic Exercise Capacity and Lung Function in Healthy Adults: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Outpatient Respiratory Management of Infants, Children, and Adolescents with Post-Prematurity Respiratory Disease: An Official American Thoracic Society Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2021Guideline
- Inspiratory and expiratory resistance cause right-to-left bubble passage through the foramen ovale.Physiological reports · 2018Trial
- Smaller coronary artery size in adults born preterm.Pediatric research · 2026Article
- Common Severity-Based Definitions of Bronchopulmonary Dysplasia Are not Associated With Outpatient Morbidities.Pediatric pulmonology · 2025Article
- Central and Peripheral Mechanisms of Low Exercise Capacity in Prematurely Born Adults.Comprehensive physiology · 2025Article
- Smaller Left Ventricular Size But Preserved Function in Adolescents and Adults Born Preterm.Journal of the American Heart Association · 2024Article
- Consequences of Preterm Birth: Knowns, Unknowns, and Barriers to Advancing Cardiopulmonary Health.Integrative and comparative biology · 2023Article
- Exercise Capacity in Very Low Birth Weight Adults: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- Microvascular and oxidative stress responses to acute high-altitude exposure in prematurely born adults.Scientific reports · 2023Article
- Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses.Frontiers in immunology · 2023Article
- Respiratory responses to hypoxia during rest and exercise in individuals born pre-term: a state-of-the-art review.European journal of applied physiology · 2022Review
- Urine and FecalMetabolites · 2022Article
- Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm.The Journal of physiology · 2022Review
- Effects of Pre-Term Birth on the Cardio-Respiratory Responses to Hypoxic Exercise in Children.Life (Basel, Switzerland) · 2022Article
- Decreased ventricular size and mass mediate the reduced exercise capacity in adolescents and adults born premature.Early human development · 2021Article
- Blunted cardiac output response to exercise in adolescents born preterm.European journal of applied physiology · 2020Article
- Respiratory and cardiopulmonary limitations to aerobic exercise capacity in adults born preterm.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Review
- Increased aortic stiffness and elevated blood pressure in response to exercise in adult survivors of prematurity.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
rationalePreterm birth, and its often-required medical interventions, can result in respiratory and gas exchange deficits into childhood. However, the long-term sequelae into adulthood are not well understood.
objectivesTo determine exercise capacity and pulmonary gas exchange efficiency during exercise in adult survivors of preterm birth.
methodsPreterm (n = 14), very low birth weight (<1,500 g) adults (20-23 yr) and term-born, age-matched control subjects (n = 16) performed incremental exercise on a cycle ergometer to volitional exhaustion while breathing one of two oxygen concentrations: normoxia (fraction of inspired oxygen, 0.21) or hypoxia (fraction of inspired oxygen, 0.12). MEASUREMENTS AND MAIN
resultsVentilation, mixed expired gases, arterial blood gases, power output, and oxygen consumption were measured during rest and exercise. We calculated the alveolar-to-arterial oxygen difference to determine pulmonary gas exchange efficiency. Preterm subjects had lower power output at volitional exhaustion than did control subjects in normoxia (150 ± 10 vs. 180 ± 10 W; P = 0.01), despite similar normoxic oxygen consumption. However, during hypoxic exercise, there was no difference in power output at volitional exhaustion between the two groups (116 ± 10 vs. 135 ± 10 W; P = 0.11). Preterm subjects also exhibited a more acidotic, acid-base balance throughout exercise compared with control subjects. In contrast to other studies, adults born preterm, as a group developed a wider alveolar-to-arterial oxygen difference and lower PaO2 than did control subjects during normoxic but not hypoxic exercise.
conclusionsThis study demonstrates that pulmonary gas exchange efficiency is lower in some adult survivors of preterm birth during exercise compared with control subjects. The gas exchange inefficiency, when present, is accompanied by low arterial blood oxygen tension. Preterm subjects also exhibit reduced power output. Overall, our findings suggest potential long-term consequences of extreme preterm birth and very low birth weight on cardiopulmonary function.
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Registered trials
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