ArticleEndocrinology2015
Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice.
Open access · bronzeAbstract read
In one paragraph
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Mechanical interplay between adipose tissues and disease progression.Bioengineering & translational medicine · 2026Review
- Therapeutic Targeting of PPARγ in Nonalcoholic Fatty Liver Disease: Efficacy, Safety, and Drug Development.Drug design, development and therapy · 2025Review
- Hdac3-deficiency increases senescence-associated distention of satellite DNA and telomere-associated foci in osteoprogenitor cells.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations.Comprehensive Physiology · 2024Review
- Article
- Deletion of FNDC5/Irisin modifies murine osteocyte function in a sex-specific manner.bioRxiv : the preprint server for biology · 2024Article
- New Insights into Calorie Restriction Induced Bone Loss.Endocrinology and metabolism (Seoul, Korea) · 2023Article
- Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging.International journal of molecular sciences · 2023Review
- The skeleton in a physical world.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.Seminars in cell & developmental biology · 2022Review
- Effects of Total Flavonoids of Epimedium on Bone Marrow Adipose Tissue in Ovariectomized Rats.Frontiers in endocrinology · 2022Article
- Generation of two multipotent mesenchymal progenitor cell lines capable of osteogenic, mature osteocyte, adipogenic, and chondrogenic differentiation.Scientific reports · 2021Article
- Review
- Association between Visceral and Bone Marrow Adipose Tissue and Bone Quality in Sedentary and Physically Active Ovariectomized Wistar Rats.Life (Basel, Switzerland) · 2021Article
- Exercise Increases Bone in SEIPIN Deficient Lipodystrophy, Despite Low Marrow Adiposity.Frontiers in endocrinology · 2021Article
- Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue.Current osteoporosis reports · 2020Review
- Bone marrow fat fraction assessment in regard to physical activity: KORA FF4-3-T MR imaging in a population-based cohort.European radiology · 2020Article
- Critical Assessment of In Vitro and In Vivo Models to Study Marrow Adipose Tissue.Current osteoporosis reports · 2020Review
- Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Reporting Guidelines, Review of Methodological Standards, and Challenges Toward Harmonization in Bone Marrow Adiposity Research. Report of the Methodologies Working Group of the International Bone Marrow Adiposity Society.Frontiers in endocrinology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Maya StynerDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Gabriel M PagnottiDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Kornelia GaliorDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Xin WuDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
William R ThompsonDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Gunes UzerDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Buer SenDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Zhihui XieDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Mark C HorowitzDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Martin A StynerDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Clinton RubinDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
Janet RubinDepartment of Medicine (M.S., K.G., X.W., G.U., B.S., Z.X., J.R.), University of North Carolina, Chapel Hill, North Carolina; Department of Physical Therapy (W.R.T.), Indiana University, Indianapolis, Indiana; Department of Computer Science (M.A.S.), University of North Carolina, Chapel Hill, North Carolina; Department of Psychiatry (M.A.S.), Image Analysis, University of North Carolina, Chapel Hill, North Carolina; Department of Biomedical Engineering (G.M.P., C.R.), Stony Brook University, Stony Brook, New York; and Department of Orthopedics and Rehabilitation (M.C.H.), Yale University, New Haven, Connecticut.
University of North Carolina at Chapel Hill · USStony Brook University · USIndiana University – Purdue University Indianapolis · USYale University · US
Funding
UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6MInterdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0MELECTRIC FIELD ATTENUATION OF OSTEOCLAST FORMATIONR01AR042360 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 1993 to 2013
$2.8MAUGMENTATION OF TRABECULAR BONE BY LOW MAGNITUDE STRAINR01AR043498 · NIAMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI RUBIN, CLINTON T · 1997 to 2012
$2.8MMechanical regulation of cytoskeleton guides beta-catenin effect on MSC fateR01AR066616 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2015 to 2019
$1.7MMechanical Control of Mesenchymal Stem Cell Lineage AllocationR01AR056655 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2010 to 2014
$1.4MHarnessing mechanical signals to control mesenchymal stem cell fateR01EB014351 · NIBIB · STATE UNIVERSITY NEW YORK STONY BROOK · PI JUDEX, STEFAN, RUBIN, CLINTON T · 2012 to 2014
$1.0MRole of C/EBPbeta in mechanical regulation of MSC potentialK08AR062097 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STYNER, MAYA SHALEV · 2012 to 2016
$651kBiophysical regulation of bone remodelingR56AR042360 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2008 to 2008
$289kNIAMS NIH HHS AR042360NIAMS NIH HHS AR056655NIAMS NIH HHS AR062097NIAMS NIH HHS AR43598NIAMS NIH HHS K08 AR062097NIAMS NIH HHS R01 AR042360NIAMS NIH HHS R01 AR043498NIAMS NIH HHS R01 AR056655NIAMS NIH HHS R01 AR066616NIAMS NIH HHS R56 AR042360NIBIB NIH HHS EB14351NIBIB NIH HHS R01 EB014351NIDDK NIH HHS DK092759NIDDK NIH HHS P30 DK056350NIDDK NIH HHS P30DK056350NIDDK NIH HHS R24 DK092759
Abstract
The contribution of marrow adipose tissue (MAT) to skeletal fragility is poorly understood. Peroxisome proliferator-activated receptor (PPAR)γ agonists, associated with increased fractures in diabetic patients, increase MAT. Here, we asked whether exercise could limit the MAT accrual and increase bone formation in the setting of PPARγ agonist treatment. Eight-week-old female C57BL/6 mice were treated with 20-mg/kg · d rosiglitazone (Rosi) and compared with control (CTL) animals. Exercise groups ran 12 km/d when provided access to running wheels (CTL exercise [CTL-E], Rosi-E). After 6 weeks, femoral MAT (volume of lipid binder osmium) and tibial bone morphology were assessed by microcomputer tomography. Rosi was associated with 40% higher femur MAT volume compared with CTL (P < .0001). Exercise suppressed MAT volume by half in CTL-E mice compared with CTL (P < .01) and 19% in Rosi-E compared with Rosi (P < .0001). Rosi treatment increased fat markers perilipin and fatty acid synthase mRNA by 4-fold (P < .01). Exercise was associated with increased uncoupling protein 1 mRNA expression in both CTL-E and Rosi-E groups (P < .05), suggestive of increased brown fat. Rosi increased cortical porosity (P < .0001) but did not significantly impact trabecular or cortical bone quantity. Importantly, exercise induction of trabecular bone volume was not prevented by Rosi (CTL-E 21% > CTL, P < .05; Rosi-E 26% > Rosi, P < .01). In summary, despite the Rosi induction of MAT extending well into the femoral diaphysis, exercise was able to significantly suppress MAT volume and induce bone formation. Our results suggest that the impact of PPARγ agonists on bone and marrow health can be partially mitigated by exercise.
Indexed as
AdipogenesisAdipose TissueAdiposityAnimalsBone DensityBone MarrowFemaleLipid MetabolismMiceMice, Inbred C57BLOsteogenesisPhysical Conditioning, AnimalPPAR gammaRosiglitazoneThiazolidinedionesPPAR gammaRosiglitazoneThiazolidinediones
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.