Evidence map›Paper›PMID 26052843›Full record

ArticleMagnetic resonance in medicine2015

All-systolic non-ECG-gated myocardial perfusion MRI: Feasibility of multi-slice continuous first-pass imaging.

Behzad Sharif, Reza Arsanjani, Rohan Dharmakumar, C Noel Bairey Merz, Daniel S Berman, Debiao Li

Open access · bronzeAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

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  10. Simple motion correction strategy reduces respiratory-induced motion artifacts for k-t accelerated and compressed-sensing cardiovascular magnetic resonance perfusion imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2018
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  14. Analysis of spatiotemporal fidelity in quantitative 3D first-pass perfusion cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Behzad SharifBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Reza ArsanjaniBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Rohan DharmakumarBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
C Noel Bairey MerzDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Daniel S BermanBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Debiao LiBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
University of California, Los Angeles · USCedars-Sinai Medical Center · USCedars-Sinai Smidt Heart Institute · US

Funding

Reliable Evaluation of Coronary Artery Disease using Myocardial BOLD MRI with CO2R01HL091989 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DHARMAKUMAR, ROHAN · 2008 to 2016
$3.5M
Whole-Heart Myocardial Blood Flow Quantification Using MRIR01HL124649 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI LI, DEBIAO · 2015 to 2018
$3.3M
Accurate Perfusion MRI for Improved Diagnosis of Microvascular Coronary DiseaseR00HL124323 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHARIF, BEHZAD · 2017 to 2019
$747k
Accurate Perfusion MRI for Improved Diagnosis of Microvascular Coronary DiseaseK99HL124323 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI SHARIF, BEHZAD · 2014 to 2015
$276k
NHLBI NIH HHS HL091989-05NHLBI NIH HHS HL124323-01NHLBI NIH HHS K99 HL124323NHLBI NIH HHS R00 HL124323NHLBI NIH HHS R01 HL091989NHLBI NIH HHS R01 HL124649
6 · The paper itself

Abstract

purposeTo develop and test the feasibility of a new method for non-ECG-gated first-pass perfusion (FPP) cardiac MR capable of imaging multiple short-axis slices at the same systolic cardiac phase.

methodsA magnetization-driven pulse sequence was developed for non-ECG-gated FPP imaging without saturation-recovery preparation using continuous slice-interleaved radial sampling. The image reconstruction method, dubbed TRACE, used self-gating based on reconstruction of a real-time image-based navigator combined with reference-constrained compressed sensing. Data from ischemic animal studies (n = 5) was used in a simulation framework to evaluate temporal fidelity. Healthy subjects (n = 5) were studied using both the proposed approach and the conventional method to compare the myocardial contrast-to-noise ratio (CNR). Patients (n = 2) underwent adenosine stress studies using the proposed method.

resultsTemporal fidelity of the developed method was shown to be sufficient at high heart-rates. The healthy volunteers studies demonstrated normal perfusion and no dark-rim artifacts. Compared with the conventional scheme, myocardial CNR for the proposed method was slightly higher (8.6 ± 0.6 versus 8.0 ± 0.7). Patient studies showed stress-induced perfusion defects consistent with invasive angiography.

conclusionThe presented methods and results demonstrate feasibility of the proposed approach for high-resolution non-ECG-gated FPP imaging of 3 myocardial slices at the same systolic phase, and indicate its potential for achieving desirable image quality (high CNR and no dark-rim artifacts).

Indexed as

AdultAlgorithmsAnimalsCardiac-Gated Imaging TechniquesCoronary Artery DiseaseDogsFeasibility StudiesFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance AngiographyMaleMyocardial IschemiaMyocardial Perfusion ImagingReproducibility of Resultscontinuous acquisitiondark rim artifactfirst-pass perfusionischemiamyocardial perfusionradial samplingreal-time navigatorsystolicungated

Identifiers

PMID26052843
PMCPMC4670813
OpenAlexW1523554838

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.