ArticleMolecular medicine (Cambridge, Mass.)2015
Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis.
Article in Molecular medicine (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03291496 (Microfluidic Assessment of Clinical Outcomes in Preterm Newborns), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Microfluidic Assessment of Clinical Outcomes in Preterm Newborns
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of Histological and Clinical Chorioamnionitis With Neonatal Sepsis Among Preterm Infants: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in immunology · 2020Pooled it
- Heterogeneity of Critical Organ Dysfunction During Late-Onset Bacteremia in Preterm Infants.JAMA network open · 2026Observational
- Exploratory Hemodynamic and Hematologic Trajectories by Culture Status Among Neonates Evaluated for Infection.Children (Basel, Switzerland) · 2026Article
- Comprehensive Analysis of Immunomodulatory-Related Genes Reveals MAPK14-Associated Myeloid-Derived Suppressor Cells Infiltration in Pediatric Sepsis.Journal of inflammation research · 2026Article
- Shared immune biomarkers in necrotizing enterocolitis and neonatal sepsis identified via bioinformatics and machine learning.Scientific reports · 2025Article
- Examining Transcriptomic Markers Associated With Neutrophil Extracellular Traps to Predict Mortality Risk in Neonatal Sepsis.Open forum infectious diseases · 2025Article
- Dual RNA isolation from blood: an optimized protocol for host and bacterial RNA purification for dual RNA-sequencing analysis in whole blood sepsis samples.Microbial genomics · 2025Article
- Age-related stress gene expression in neonatal sepsis involves regulatory networks and immune cell infiltration.Scientific reports · 2025Article
- Immunomodulation in Pediatric Sepsis: A Narrative Review.Journal of clinical medicine · 2025Review
- Heterogeneity of Neutrophils and Immunological Function in Neonatal Sepsis: Analysis of Molecular Subtypes Based on Hypoxia-Glycolysis-Lactylation.Mediators of inflammation · 2025Article
- Evaluation of whole blood CD64 for identifying infection in neonates receiving hospital care.Frontiers in immunology · 2025Article
- Transcriptomic mortality signature defines high-risk neonatal sepsis endotype.Frontiers in immunology · 2025Article
- Associations between maternal bacteremia during the peripartum period and early-onset neonatal sepsis: a retrospective cohort study.BMC pediatrics · 2024Article
- Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies.Nature communications · 2024Article
- The molecular landscape of sepsis severity in infants: enhanced coagulation, innate immunity, and T cell repression.Frontiers in immunology · 2024Article
- Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants.Children (Basel, Switzerland) · 2023Review
- Identification and verification of feature biomarkers associated with immune cells in neonatal sepsis.European journal of medical research · 2023Article
- Identification of key biomarkers in neonatal sepsis by integrated bioinformatics analysis and clinical validation.Heliyon · 2022Article
- The balance between protective and pathogenic immune responses to pneumonia in the neonatal lung is enforced by gut microbiota.Science translational medicine · 2022Article
- Transcriptome profiles discriminate between Gram-positive and Gram-negative sepsis in preterm neonates.Pediatric research · 2022Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Neonates manifest a unique host response to sepsis even among other children. Preterm neonates may experience sepsis soon after birth or during often-protracted birth hospitalizations as they attain physiologic maturity. We examined the transcriptome using genome-wide expression profiling on prospectively collected peripheral blood samples from infants evaluated for sepsis within 24 h after clinical presentation. Simultaneous plasma samples were examined for alterations in inflammatory mediators. Group designation (sepsis or uninfected) was determined retrospectively on the basis of clinical exam and laboratory results over the next 72 h from the time of evaluation. Unsupervised analysis showed the major node of separation between groups was timing of sepsis episode relative to birth (early, <3 d, or late, ≥3 d). Principal component analyses revealed significant differences between patients with early or late sepsis despite the presence of similar key immunologic pathway aberrations in both groups. Unique to neonates, the uninfected state and host response to sepsis is significantly affected by timing relative to birth. Future therapeutic approaches may need to be tailored to the timing of the infectious event based on postnatal age.
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