ArticleeLife2015
The unfolded protein response is required for dendrite morphogenesis.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- A human-specific microRNA controls the timing of excitatory synaptogenesis.Nature communications · 2026Article
- Disease modeling of myocilin mutation-dependent normal tension glaucoma: human retinal ganglion cell susceptibility to unfolded protein response and mTOR signaling.Stem cells (Dayton, Ohio) · 2026Article
- Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.Scientific reports · 2025Article
- Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.Nature communications · 2024Article
- Histone deacetylase inhibition expands cellular proteostasis repertoires to enhance neuronal stress resilience.bioRxiv : the preprint server for biology · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- High-Dose Ionizing Radiation Impairs Healthy Dendrite Growth inAdvances in radiation oncology · 2024Article
- The Caenorhabditis elegans anchor cell transcriptome: ribosome biogenesis drives cell invasion through basement membrane.Development (Cambridge, England) · 2023Article
- Long noncoding RNA Gm2694 drives depressive-like behaviors in male mice by interacting with GRP78 to disrupt endoplasmic reticulum homeostasis.Science advances · 2022Article
- Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning.EMBO reports · 2022Article
- Live imaging of postembryonic developmental processes inSTAR protocols · 2022Article
- Neuronal regulatedeLife · 2021Article
- Article
- Deep learning-enabled analysis reveals distinct neuronal phenotypes induced by aging and cold-shock.BMC biology · 2020Article
- Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.PLoS genetics · 2020Article
- Review
- AG3 (Bethesda, Md.) · 2020Article
- Homeostatic Roles of the Proteostasis Network in Dendrites.Frontiers in cellular neuroscience · 2020Review
- Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.Developmental biology · 2019Review
- Atlastin-1 regulates morphology and function of endoplasmic reticulum in dendrites.Nature communications · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Precise patterning of dendritic fields is essential for the formation and function of neuronal circuits. During development, dendrites acquire their morphology by exuberant branching. How neurons cope with the increased load of protein production required for this rapid growth is poorly understood. Here we show that the physiological unfolded protein response (UPR) is induced in the highly branched Caenorhabditis elegans sensory neuron PVD during dendrite morphogenesis. Perturbation of the IRE1 arm of the UPR pathway causes loss of dendritic branches, a phenotype that can be rescued by overexpression of the ER chaperone HSP-4 (a homolog of mammalian BiP/grp78). Surprisingly, a single transmembrane leucine-rich repeat protein, DMA-1, plays a major role in the induction of the UPR and the dendritic phenotype in the UPR mutants. These findings reveal a significant role for the physiological UPR in the maintenance of ER homeostasis during morphogenesis of large dendritic arbors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.