Evidence map›Paper›PMID 26052548›Full record

ArticleJournal of nature and science2015

Effect of Sodium Fluoride on the endogenous MMP Activity of Dentin Matrices.

Martha Goël Brackett, Kelli A Agee, William W Brackett, William O Key, Camila Sabatini, Melissa T Kato, Marilia A R Buzalaf, Leo Tjäderhane, David H Pashley

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of nature and science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Article
  3. Matrix metalloproteinase inhibitors in restorative dentistry.Journal of conservative dentistry and endodontics · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Effect of Silver Nitrate and Sodium Fluoride with Tri-Calcium Phosphate onInternational journal of molecular sciences · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Martha Goël BrackettDepartment of Oral Rehabilitation, Georgia Regents University, College of Dental Medicine, Augusta, GA, USA.
Kelli A AgeeDepartment of Oral Biology, Georgia Regents University, College of Dental Medicine, Augusta, GA, USA.
William W BrackettDepartment of Oral Rehabilitation, Georgia Regents University, College of Dental Medicine, Augusta, GA, USA.
William O KeyDepartment of Oral Rehabilitation, Georgia Regents University, College of Dental Medicine, Augusta, GA, USA.
Camila SabatiniDepartment of Restorative Dentistry, School of Dental Medicine, Buffalo, Buffalo, NY, USA.
Melissa T KatoDepartment of Biological Sciences, Bauru School of Dentistry, USP University of São Paulo, Bauru, SP, Brazil.
Marilia A R BuzalafDepartment of Biological Sciences, Bauru School of Dentistry, USP University of São Paulo, Bauru, SP, Brazil.
Leo TjäderhaneInstitute of Dentistry, University of Oulu and Oulu University Hospital, Oulu, Finland; and Institute of Dentistry, University of Turku, Turku, Finland.
David H PashleyDepartment of Oral Biology, Georgia Regents University, College of Dental Medicine, Augusta, GA, USA.
Georgia Regents Medical Center · USUniversidade de São Paulo · BRAugusta University · USUniversity at Buffalo, State University of New York · US

Funding

Reasons for poor durability of resin-dentin bondsR01DE015306 · NIDCR · MEDICAL COLLEGE OF GEORGIA (MCG) · PI PASHLEY, DAVID H · 2004 to 2013
$4.4M
NIDCR NIH HHS R01 DE015306
6 · The paper itself

Abstract

objectivesThis study evaluated the effect of incorporating increasing concentrations of sodium fluoride in incubation media, on the loss of dry mass and solubilization of collagen from demineralized dentin beams incubated for up to 7 days. The effect of fluoride on the inhibition of matrix-bound metalloproteinases (MMPs) was also measured.

methodsDentin beams were completely demineralized in 10% phosphoric acid. After baseline measurements of dry mass, the beams were divided into six groups (n=10) and incubated at 37°C either in buffered media containing sodium fluoride (NaF) at 75, 150, 300, 450, 600 ppm or in fluoride-free media (control) for seven days. Following incubation, dry mass was re-measured. The incubation media was hydrolyzed with HCl for the quantitation of hydroxyproline (HYP) as an index of solubilization of collagen by endogenous dentin proteases. Increasing concentrations of fluoride were also evaluated for their ability to inhibit rhMMP-9.

resultsAddition of NaF to the incubation media produced a progressive significant reduction (p<0.05) in the loss of mass of dentin matrices, with all concentrations demonstrating significantly less mass loss than the control group. Significantly less HYP release from the dentin beams was found in the higher fluoride concentration groups, while fluoride concentrations of 75 and 150 ppm significantly reduced rhMMP-9 activity by 6.5% and 79.2%, respectively.

conclusionsThe results of this study indicate that NaF inhibits matrix-bound MMPs and therefore may slow the degradation of dentin matrix by endogenous dentin MMPs.

Indexed as

Dentindry mass lossmatrix metalloproteinasesNaFstorage solution

Identifiers

PMID26052548
PMCPMC4457332
OpenAlexW1504028812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.