ReviewFrontiers in chemistry2015
Endophytic and epiphytic microbes as "sources" of bioactive agents.
Review in Frontiers in chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Antibacterial activity of marine macroalgae-associated Bacillus spp. from the Bay of Bengal coast of India.Antonie van Leeuwenhoek · 2026Article
- Diversity, bioactivities, and metabolomics of culturable endophytic fungi from the medicinal plantFrontiers in microbiology · 2026Article
- Antibacterial and antioxidant potentials, detection of host origin compounds, and metabolic profiling of endophytic Bacillus spp. isolated from Rauvolfia serpentina (L.) Benth. ex Kurz.Scientific reports · 2025Article
- Medicinal Plant Microbiomes: Factors Affecting Bacterial and Fungal Community Composition.Planta medica · 2024Article
- Endophytic Fungi Volatile Organic Compounds as Crucial Biocontrol Agents Used for Controlling Fruit and Vegetable Postharvest Diseases.Journal of fungi (Basel, Switzerland) · 2024Review
- Interaction ofFrontiers in pharmacology · 2024Article
- Unveiling the anticancer potential of the ethanolic extract fromFrontiers in pharmacology · 2024Article
- Media optimization of antimicrobial activity production and beta-glucan content of endophytic fungiBiotechnology reports (Amsterdam, Netherlands) · 2022Article
- Metabolites of endophytic fungi isolated from leaves ofFrontiers in fungal biology · 2022Article
- Huoshanmycins A‒C, New Polyketide Dimers Produced by EndophyticFrontiers in chemistry · 2021Article
- Targeted Isolation of Anti-Trypanosomal Naphthofuran-Quinone Compounds from the Mangrove PlantMarine drugs · 2020Article
- Article
- Creating and screening natural product libraries.Natural product reports · 2020Review
- Antimicrobial Activity of Microorganisms Isolated from Ant Nests ofLife (Basel, Switzerland) · 2020Article
- The Role of Endophytic/Epiphytic Bacterial Constituents in the Immunostimulatory Activity of the Botanical,The Yale journal of biology and medicine · 2020Article
- New chlamydosporol derivatives from the endophytic fungus Pleosporales sp. Sigrf05 and their cytotoxic and antimicrobial activities.Scientific reports · 2020Article
- Patents on Endophytic Fungi Related to Secondary Metabolites and Biotransformation Applications.Journal of fungi (Basel, Switzerland) · 2020Review
- New peptidendrocins and anticancer chartreusin from an endophytic bacterium ofAnnals of translational medicine · 2020Article
- Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes.Frontiers in pharmacology · 2020Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beginning with the report by Stierle and Strobel in 1993 on taxol((R)) production by an endophytic fungus (Stierle et al., 1993), it is possible that a number of the agents now used as leads to treatments of diseases in man, are not produced by the plant or invertebrate host from which they were first isolated and identified. They are probably the product of a microbe in, on or around the macroorganism. At times there is an intricate "dance" between a precursor produced by a microbe, and interactions within the macroorganism, or in certain cases, a fungus, that ends up with the production of a novel agent that has potential as a treatment for a human disease. This report will give examples from insects, plants, and marine invertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.