ReviewFrontiers in chemistry2015
Bioinspired iterative synthesis of polyketides.
Review in Frontiers in chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Stereoselective Epimerization of 1,3-Diols Using a Chiral Hydrogen Atom Abstraction Catalyst.Journal of the American Chemical Society · 2026Article
- Antiviral Activity of Polyene Macrolides Against Newcastle Disease Virus: Computational and Experimental Insights.Molecules (Basel, Switzerland) · 2026Article
- Ring opening of epoxides: a facile approach towards the synthesis of polyketides and related stereoenriched natural products: a review.Molecular diversity · 2025Review
- Photoenolization ofJournal of the American Chemical Society · 2025Article
- A Three-Step Catalytic Asymmetric Sequence from Alkynes to α-Silyloxyaldehydes and Its Application to a C22-C41 Fragment of Bastimolide A.Organic letters · 2024Article
- Stereocontrolled Total Synthesis of Bastimolide B Using Iterative Homologation of Boronic Esters.Journal of the American Chemical Society · 2022Article
- The Quest for Novel Antimicrobial Compounds: Emerging Trends in Research, Development, and Technologies.Antibiotics (Basel, Switzerland) · 2019Review
- Structurally Diverse Polyketides From the Mangrove-Derived FungusFrontiers in chemistry · 2018Article
- Iterative assembly line synthesis of polypropionates with full stereocontrol.Nature chemistry · 2017Article
- Syntheses of Denudatine Diterpenoid Alkaloids: Cochlearenine, N-Ethyl-1α-hydroxy-17-veratroyldictyzine, and Paniculamine.Journal of the American Chemical Society · 2016Article
- An unusual intramolecularTetrahedron · 2016Article
- Amino acid-derived defense metabolites from plants: A potential source to facilitate novel antimicrobial development.The Journal of biological chemistryReview
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diverse array of biopolymers and second metabolites (particularly polyketide natural products) has been manufactured in nature through an enzymatic iterative assembly of simple building blocks. Inspired by this strategy, molecules with inherent modularity can be efficiently synthesized by repeated succession of similar reaction sequences. This privileged strategy has been widely adopted in synthetic supramolecular chemistry. Its value also has been reorganized in natural product synthesis. A brief overview of this approach is given with a particular emphasis on the total synthesis of polyol-embedded polyketides, a class of vastly diverse structures and biologically significant natural products. This viewpoint also illustrates the limits of known individual modules in terms of diastereoselectivity and enantioselectivity. More efficient and practical iterative strategies are anticipated to emerge in the future development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.