ArticleEuropean journal of translational myology2015
Skeletal muscle triad junction ultrastructure by Focused-Ion-Beam milling of muscle and Cryo-Electron Tomography.
Article in European journal of translational myology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Cylindrical Crystallization of CaInternational journal of molecular sciences · 2026Review
- In situ structural insights into the excitation-contraction coupling mechanism of skeletal muscle.Science advances · 2024Article
- CaInternational journal of molecular sciences · 2023Article
- Electron microscopy of cardiac 3D nanodynamics: form, function, future.Nature reviews. Cardiology · 2022Review
- Cryo-FIB preparation of whole cells and tissue for cryo-TEM: use of high-pressure frozen specimens in tubes and planchets.Journal of microscopy · 2021Article
- Preparing samples from whole cells using focused-ion-beam milling for cryo-electron tomography.Nature protocols · 2020Article
- Structure of RyR1 in native membranes.EMBO reports · 2020Article
- After the revolution: how is Cryo-EM contributing to muscle research?Journal of muscle research and cell motility · 2019Review
- A proposed role for non-junctional transverse tubules in skeletal muscle as flexible segments allowing expansion of the transverse network.European journal of translational myology · 2019Article
- Mobility disorders and pain, interrelations that need new research concepts and advanced clinical commitments.European journal of translational myology · 2017Article
- Cryo-FIB specimen preparation for use in a cartridge-type cryo-TEM.Journal of structural biology · 2017Article
- Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes.European journal of translational myology · 2016Article
- Imaging Approaches in Functional Assessment of Implantable Myogenic Biomaterials and Engineered Muscle Tissue.European journal of translational myology · 2015Review
- Electron Microscopy: From 2D to 3D Images with Special Reference to Muscle.European journal of translational myology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cryo-electron tomography (cryo-ET) has emerged as perhaps the only practical technique for revealing nanometer-level three-dimensional structural details of subcellular macromolecular complexes in their native context, inside the cell. As currently practiced, the specimen should be 0.1- 0.2 microns in thickness to achieve optimal resolution. Thus, application of cryo-ET to intact frozen (vitreous) tissues, such as skeletal muscle, requires that they be sectioned. Cryo-ultramicrotomy is notoriously difficult and artifact-prone when applied to frozen cells and tissue, but a new technique, focused ion beam milling (cryo-FIB), shows great promise for "thinning" frozen biological specimens. Here we describe our initial results in applying cryo-FIB and cryo-ET to triad junctions of skeletal muscle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.