Evidence map›Paper›PMID 26052394›Full record

ReviewWorld journal of hepatology2015

Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma.

Loukia S Poulou, Evanthia Botsa, Ioanna Thanou, Panayiotis D Ziakas, Loukas Thanos

Registry-linked trialOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05471596 (Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics in Hepato-Pancreato-Biliary Solid Tumors), which is not on this map. Cited by 166 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 8 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05471596 completednot on this mapstarted 2022, after this paper: background citation

Prospective Analysis of In Vivo Laparoscopic Microwave Ablation Thermodynamics in Hepato-Pancreato-Biliary Solid Tumors

Typeobservational_patient_registrySponsorWake Forest University Health SciencesRan2022 to 2023Enrolled60ConditionsLiver DiseasesArmsNeuWave Microwave Ablation System
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 8 syntheses or guidelines pooled it, 317 citations in OpenAlex.

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106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Loukia S PoulouLoukia S Poulou, Research Unit in Radiology and Medical Imaging, Evgenidion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Evanthia BotsaLoukia S Poulou, Research Unit in Radiology and Medical Imaging, Evgenidion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Ioanna ThanouLoukia S Poulou, Research Unit in Radiology and Medical Imaging, Evgenidion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Panayiotis D ZiakasLoukia S Poulou, Research Unit in Radiology and Medical Imaging, Evgenidion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Loukas ThanosLoukia S Poulou, Research Unit in Radiology and Medical Imaging, Evgenidion Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece.
Brown University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse, steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency (RFA) and microwave ablation (MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent (approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival.

Indexed as

AblationHepatocellular carcinomaMicrowavePercutaneousRadiofrequency

Identifiers

PMID26052394
PMCPMC4450182
OpenAlexW2406438510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.