Evidence map›Paper›PMID 26052384›Full record

ReviewWorld journal of hepatology2015

Chemokines and their receptors play important roles in the development of hepatocellular carcinoma.

Chun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of hepatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. EMT and Inflammation: Crossroads in HCC.Journal of gastrointestinal cancer · 2023
    Review
  5. Article
  6. Review
  7. Investigation of Anti-Liver Cancer Activity of the Herbal Drug FDY003 Using Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. International journal of general medicine · 2021
    Article
  17. Article
  18. Article
  19. Article
  20. Dual CCR5/CCR2 targeting: opportunities for the cure of complex disorders.Cellular and molecular life sciences : CMLS · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Chun-Min LiangChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Long ChenChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Heng HuChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Hui-Ying MaChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Ling-Ling GaoChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Jie QinChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Cui-Ping ZhongChun-Min Liang, Long Chen, Heng Hu, Hui-Ying Ma, Ling-Ling Gao, Jie Qin, Cui-Ping Zhong, Lab of Tumor Immunology, Department of Anatomy and Histology and Embryology, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Shanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The chemokine system consists of four different subclasses with over 50 chemokines and 19 receptors. Their functions in the immune system have been well elucidated and research during the last decades unveils their new roles in hepatocellular carcinoma (HCC). The chemokines and their receptors in the microenvironment influence the development of HCC by several aspects including: inflammation, effects on immune cells, angiogenesis, and direct effects on HCC cells. Regarding these aspects, pre-clinical research by targeting the chemokine system has yielded promising data, and these findings bring us new clues in the chemokine-based therapies for HCC.

Indexed as

AngiogenesisChemokine receptorsChemokinesHepatocellular carcinomaImmune cellsInflammationTreatmentsTumor behaviors

Identifiers

PMID26052384
PMCPMC4450202
OpenAlexW2409483347

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.