ReviewFrontiers in immunology2015
Tweeters, Woofers and Horns: The Complex Orchestration of Calcium Currents in T Lymphocytes.
Review in Frontiers in immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Review
- How the Potassium Channel Response of T Lymphocytes to the Tumor Microenvironment Shapes Antitumor Immunity.Cancers · 2022Review
- An integrated cytokine and kynurenine network as the basis of neuroimmune communication.Frontiers in neuroscience · 2022Review
- Deregulated calcium signaling in blood cancer: Underlying mechanisms and therapeutic potential.Frontiers in oncology · 2022Review
- New Insights on the Role of TRP Channels in Calcium Signalling and Immunomodulation: Review of Pathways and Implications for Clinical Practice.Clinical reviews in allergy & immunology · 2021Review
- Inhibitory effects ofPeerJ · 2021Article
- AiScience · 2020Article
- Neurokinin-1 Receptor Signaling Is Required for Efficient CaCell reports · 2020Article
- Competitive glucose metabolism as a target to boost bladder cancer immunotherapy.Nature reviews. Urology · 2020Review
- Mutation of an L-Type Calcium Channel Gene Leads to T Lymphocyte Dysfunction.Frontiers in immunology · 2019Article
- IL-17A-Mediated Excessive Autophagy Aggravated Neuronal Ischemic Injuries via Src-PP2B-mTOR Pathway.Frontiers in immunology · 2019Article
- Rough Titanium Oxide Coating Prepared by Micro-Arc Oxidation Causes Down-Regulation of hTERT Expression, Molecular Presentation, and Cytokine Secretion in Tumor Jurkat T Cells.Materials (Basel, Switzerland) · 2018Article
- The Transient Receptor Potential Vanilloid 1 Is Associated with Active Inflammation in Ulcerative Colitis.Mediators of inflammation · 2018Article
- Article
- Modulation of Endoplasmic Reticulum Stress Controls CD4Cancer immunology research · 2017Article
- Distinct patterns of cytolytic T-cell activation by different tumour cells revealed by CaImmunology · 2017Article
- Immunological Disorders: Regulation of CaAdvances in experimental medicine and biology · 2017Review
- Characterization of the Syk-Dependent T Cell Signaling Response to an Altered Peptide.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments.Molecular pharmaceutics · 2016Article
- Transient Receptor Potential (TRP) channels in T cells.Seminars in immunopathology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Elevation of intracellular calcium ion (Ca(2+)) levels is a vital event that regulates T lymphocyte homeostasis, activation, proliferation, differentiation, and apoptosis. The mechanisms that regulate intracellular Ca(2+) signaling in lymphocytes involve tightly controlled concinnity of multiple ion channels, membrane receptors, and signaling molecules. T cell receptor (TCR) engagement results in depletion of endoplasmic reticulum (ER) Ca(2+) stores and subsequent sustained influx of extracellular Ca(2+) through Ca(2+) release-activated Ca(2+) (CRAC) channels in the plasma membrane. This process termed store-operated Ca(2+) entry (SOCE) involves the ER Ca(2+) sensing molecule, STIM1, and a pore-forming plasma membrane protein, ORAI1. However, several other important Ca(2+) channels that are instrumental in T cell function also exist. In this review, we discuss the role of additional Ca(2+) channel families expressed on the plasma membrane of T cells that likely contribute to Ca(2+) influx following TCR engagement, which include the TRP channels, the NMDA receptors, the P2X receptors, and the IP3 receptors, with a focus on the voltage-dependent Ca(2+) (CaV) channels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.