ReviewFrontiers in aging neuroscience2015
On the central role of brain connectivity in neurodegenerative disease progression.
Review in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hubs of long-distance co-alteration characterize brain pathology.Human brain mapping · 2020Pooled it
- Advanced neuroimaging assessment of neurodegenerative dementia syndromes: A framework for comprehensive multimodal FDG-PET, MR-perfusion, and MR-diffusion analysis.NeuroImage. Clinical · 2026Article
- White matter dysfunction in Alzheimer's disease is associated with disease-related transcriptomic signatures.Communications biology · 2025Article
- Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions.eLife · 2024Article
- Article
- Revealing the combined roles of Aβ and tau in Alzheimer's disease via a pathophysiological activity decoder.bioRxiv : the preprint server for biology · 2023Article
- Common neural substrates of diverse neurodevelopmental disorders.Brain : a journal of neurology · 2023Article
- Cognitive training based on functional near-infrared spectroscopy neurofeedback for the elderly with mild cognitive impairment: a preliminary study.Frontiers in aging neuroscience · 2023Article
- The Myelin-Weighted Connectome in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Article
- The human connectome in Alzheimer disease - relationship to biomarkers and genetics.Nature reviews. Neurology · 2021Review
- Interhemispheric co-alteration of brain homotopic regions.Brain structure & function · 2021Article
- Retrotransposons as a Source of DNA Damage in Neurodegeneration.Frontiers in aging neuroscience · 2021Review
- Finding specificity in structural brain alterations through Bayesian reverse inference.Human brain mapping · 2020Article
- Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease.Nature communications · 2020Article
- Differences in topological progression profile among neurodegenerative diseases from imaging data.eLife · 2019Article
- A cross-disorder connectome landscape of brain dysconnectivity.Nature reviews. Neuroscience · 2019Review
- The Lifespan Human Connectome Project in Aging: An overview.NeuroImage · 2019Article
- The alteration landscape of the cerebral cortex.NeuroImage · 2019Article
- Brain structural alterations are distributed following functional, anatomic and genetic connectivity.Brain : a journal of neurology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased brain connectivity, in all its variants, is often considered an evolutionary advantage by mediating complex sensorimotor function and higher cognitive faculties. Interaction among components at all spatial scales, including genes, proteins, neurons, local neuronal circuits and macroscopic brain regions, are indispensable for such vital functions. However, a growing body of evidence suggests that, from the microscopic to the macroscopic levels, such connections might also be a conduit for in intra-brain disease spreading. For instance, cell-to-cell misfolded proteins (MP) transmission and neuronal toxicity are prominent connectivity-mediated factors in aging and neurodegeneration. This article offers an overview of connectivity dysfunctions associated with neurodegeneration, with a specific focus on how these may be central to both normal aging and the neuropathologic degenerative progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.