Evidence map›Paper›PMID 26052283›Full record

ArticleFrontiers in aging neuroscience2015

Anterior cingulate cortex mediates the relationship between O3PUFAs and executive functions in APOE e4 carriers.

Marta K Zamroziewicz, Erick J Paul, Rachael D Rubin, Aron K Barbey

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. 2D:4D digit ratio and brain volumes in alcohol use disorder.European archives of psychiatry and clinical neuroscience · 2026
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  7. Brain communications · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marta K ZamroziewiczDecision Neuroscience Laboratory, University of Illinois Urbana, IL, USA ; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana, IL, USA ; Neuroscience Program, University of Illinois Champaign, IL, USA.
Erick J PaulDecision Neuroscience Laboratory, University of Illinois Urbana, IL, USA ; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana, IL, USA.
Rachael D RubinDecision Neuroscience Laboratory, University of Illinois Urbana, IL, USA ; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana, IL, USA ; Carle Neuroscience Institute, Carle Foundation Hospital Urbana, IL, USA.
Aron K BarbeyDecision Neuroscience Laboratory, University of Illinois Urbana, IL, USA ; Beckman Institute for Advanced Science and Technology, University of Illinois Urbana, IL, USA ; Neuroscience Program, University of Illinois Champaign, IL, USA ; Department of Speech and Hearing Science, University of Illinois Champaign, IL, USA ; Department of Internal Medicine, University of Illinois Champaign, IL, USA ; Institute for Genomic Biology, University of Illinois Champaign, IL, USA ; Department of Psychology, University of Illinois Champaign, IL, USA.
University of Illinois Urbana-Champaign · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough diet has a substantial influence on the aging brain, the relationship between biomarkers of diet and aspects of brain health remains unclear. This study examines the neural mechanisms that mediate the relationship between omega-3 polyunsaturated fatty acids (O3PUFAs) and executive functions in at-risk (APOE e4 carriers), cognitively intact older adults. We hypothesized that higher levels of O3PUFAs are associated with better performance in a particular component of the executive functions, namely cognitive flexibility, and that this relationship is mediated by gray matter volume of a specific region thought to be important for cognitive flexibility, the anterior cingulate cortex.

methodsWe examined 40 cognitively intact adults between the ages of 65 and 75 with the APOE e4 polymorphism to investigate the relationship between biomarkers of O3PUFAs, tests of cognitive flexibility (measured by the Delis-Kaplan Executive Function System Trail Making Test), and gray matter volume within regions of the prefrontal cortex (PFC).

resultsA mediation analysis revealed that gray matter volume within the left rostral anterior cingulate cortex partially mediates the relationship between O3PUFA biomarkers and cognitive flexibility.

conclusionThese results suggest that the anterior cingulate cortex acts as a mediator of the relationship between O3PUFAs and cognitive flexibility in cognitively intact adults thought to be at risk for cognitive decline. Through their link to executive functions and neuronal measures of PFC volume, O3PUFAs show potential as a nutritional therapy to prevent dysfunction in the aging brain.

Indexed as

anterior cingulate cortexcognitive agingexecutive functionnutritional neuroscienceomega-3 fatty acids

Identifiers

PMID26052283
PMCPMC4439554
OpenAlexW1601158657

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.