Evidence map›Paper›PMID 26052269›Full record

ReviewFrontiers in cellular neuroscience2015

Advances in imaging ultrastructure yield new insights into presynaptic biology.

Joseph J Bruckner, Hong Zhan, Kate M O'Connor-Giles

Abstract readReview
In one paragraph

Review in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Nanomachinery Organizing Release at Neuronal and Ribbon Synapses.International journal of molecular sciences · 2019
    Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph J BrucknerCell and Molecular Biology Training Program, University of Wisconsin-Madison Madison, WI, USA.
Hong ZhanLaboratory of Cell and Molecular Biology, University of Wisconsin-Madison Madison, WI, USA.
Kate M O'Connor-GilesCell and Molecular Biology Training Program, University of Wisconsin-Madison Madison, WI, USA ; Laboratory of Cell and Molecular Biology, University of Wisconsin-Madison Madison, WI, USA ; Laboratory of Genetics, University of Wisconsin-Madison Madison, WI, USA.

Funding

Molecular mechanisms of synapse assembly and functionR01NS078179 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI O'CONNOR-GILES, KATHALEEN M · 2013 to 2023
$3.6M
NINDS NIH HHS R01 NS078179
6 · The paper itself

Abstract

Synapses are the fundamental functional units of neural circuits, and their dysregulation has been implicated in diverse neurological disorders. At presynaptic terminals, neurotransmitter-filled synaptic vesicles are released in response to calcium influx through voltage-gated calcium channels activated by the arrival of an action potential. Decades of electrophysiological, biochemical, and genetic studies have contributed to a growing understanding of presynaptic biology. Imaging studies are yielding new insights into how synapses are organized to carry out their critical functions. The development of techniques for rapid immobilization and preservation of neuronal tissues for electron microscopy (EM) has led to a new renaissance in ultrastructural imaging that is rapidly advancing our understanding of synapse structure and function.

Indexed as

active zoneelectron microscopypresynapsesynaptic vesicleultrastructure

Identifiers

PMID26052269
PMCPMC4440913

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.