Evidence map›Paper›PMID 26052039›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015

Increased Serotonin Transporter Expression Reduces Fear and Recruitment of Parvalbumin Interneurons of the Amygdala.

Marco Bocchio, Giulia Fucsina, Lydia Oikonomidis, Stephen B McHugh, David M Bannerman, Trevor Sharp, Marco Capogna

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
8.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Emotional Memory Processing during REM Sleep with Implications for Post-Traumatic Stress Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  9. Review
  10. Article
  11. Effects of a psychedelic 5-HT2A receptor agonist on anxiety-related behavior and fear processing in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Inhibition in the amygdala anxiety circuitry.Experimental & molecular medicine · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Marco BocchioMRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7005-3453
Giulia FucsinaMRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
Lydia OikonomidisMRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
Stephen B McHughDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
David M BannermanDepartment of Experimental Psychology, University of Oxford, Oxford, UK.
Trevor SharpDepartment of Pharmacology, University of Oxford, Oxford, UK.
Marco CapognaMRC Brain Network Dynamics Unit, Department of Pharmacology, University of Oxford, Oxford, UK.
University of Oxford · GB

Funding

Medical Research Council MC_U138162360Medical Research Council MC_UU_12020/2Wellcome Trust 087736
6 · The paper itself

Abstract

Genetic association studies suggest that variations in the 5-hydroxytryptamine (5-HT; serotonin) transporter (5-HTT) gene are associated with susceptibility to psychiatric disorders such as anxiety or posttraumatic stress disorder. Individuals carrying high 5-HTT-expressing gene variants display low amygdala reactivity to fearful stimuli. Mice overexpressing the 5-HTT (5-HTTOE), an animal model of this human variation, show impaired fear, together with reduced fear-evoked theta oscillations in the basolateral amygdala (BLA). However, it is unclear how variation in 5-HTT gene expression impacts on the microcircuitry of the BLA to change behavior. We addressed this issue by investigating the activity of parvalbumin (PV)-expressing interneurons (PVINs), the biggest IN population in the basal amygdala (BA). We found that increased 5-HTT expression impairs the recruitment of PVINs (measured by their c-Fos immunoreactivity) during fear. Ex vivo patch-clamp recordings demonstrated that the depolarizing effect of 5-HT on PVINs was mediated by 5-HT2A receptor. In 5-HTTOE mice, 5-HT-evoked depolarization of PVINs and synaptic inhibition of principal cells, which provide the major output of the BA, were impaired. This deficit was because of reduced 5-HT2A function and not because of increased 5-HT uptake. Collectively, these findings provide novel cellular mechanisms that are likely to contribute to differences in emotional behaviors linked with genetic variations of the 5-HTT.

Indexed as

Action PotentialsAnimalsAuditory PerceptionBasolateral Nuclear ComplexConditioning, PsychologicalElectroshockFearFemaleFreezing Reaction, CatalepticImmunohistochemistryInterneuronsMice, Inbred C57BLMice, Inbred CBAMice, TransgenicNeural InhibitionParvalbuminsParvalbuminsProto-Oncogene Proteins c-fosReceptor, Serotonin, 5-HT2ASerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouse

Identifiers

PMID26052039
PMCPMC4864439
OpenAlexW654134963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.