Evidence map›Paper›PMID 26052005›Full record

ReviewTrends in cell biology2015

Single-molecule insights into mRNA dynamics in neurons.

Adina R Buxbaum, Young J Yoon, Robert H Singer, Hye Yoon Park

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 81 citations in OpenAlex.

  1. A miniature bioluminescent platform for imaging structured RNAs.bioRxiv : the preprint server for biology · 2026
    Article
  2. Synaptic Proteostasis in Health and Disease.Journal of neurochemistry · 2026
    Review
  3. Article
  4. Article
  5. Applications and development of in situ nucleic acid visualization techniques.Frontiers in bioengineering and biotechnology · 2026
    Review
  6. Review
  7. Article
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  13. Tagged actin mRNA dysregulation in IGF2BP1[Formula: see text] mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
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  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Adina R BuxbaumDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA; Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA; Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
Young J YoonDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Robert H SingerDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA; Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA; Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA.
Hye Yoon ParkJanelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA; Department of Physics and Astronomy, Seoul National University, Seoul 151-747, Korea; Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Korea. Electronic address: hyeyoon.park@snu.ac.kr.
Albert Einstein College of Medicine · USHoward Hughes Medical Institute · USJanelia Research Campus · USSeoul National University · KR

Funding

Mechanism of MRNA Localization and Localized Translation in NeuronsR01NS083085 · NINDS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sulagna Das, Robert H Singer · 2013 to 2026
$9.0M
NINDS NIH HHS NS083085-19NINDS NIH HHS R01 NS083085
6 · The paper itself

Abstract

Targeting of mRNAs to neuronal dendrites and axons plays an integral role in intracellular signaling, development, and synaptic plasticity. Single-molecule imaging of mRNAs in neurons and brain tissue has led to enhanced understanding of mRNA dynamics. Here we discuss aspects of mRNA regulation as revealed by single-molecule detection, which has led to quantitative analyses of mRNA diversity, localization, transport, and translation. These exciting new discoveries propel our understanding of the life of an mRNA in a neuron and how its activity is regulated at the single-molecule level.

Indexed as

AnimalsHumansIn Situ Hybridization, FluorescenceIntracellular MembranesNeuronal PlasticityNeuronsProtein BiosynthesisRNA, MessengerSignal TransductionRNA, Messengerlocal translationmRNA trackingRNA localizationsmFISH

Identifiers

PMID26052005
PMCPMC4515374
OpenAlexW1718147747

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.