Evidence map›Paper›PMID 26051423›Full record

ArticleNeuron2015

Representations of Taste Modality in the Drosophila Brain.

David T Harris, Benjamin R Kallman, Brendan C Mullaney, Kristin Scott

Abstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The role of GABA in modulation of taste signaling within the taste bud.Pflugers Archiv : European journal of physiology · 2024
    Article
  10. Article
  11. Article
  12. Connectomic analysis of taste circuits inbioRxiv : the preprint server for biology · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. Delineating Purinergic Signaling inInternational journal of molecular sciences · 2022
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David T HarrisDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Benjamin R KallmanDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Brendan C MullaneyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Kristin ScottDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address: kscott@berkeley.edu.

Funding

Processing Gustatory Information in the Fly BrainR01DC013280 · NIDCD · UNIVERSITY OF CALIFORNIA BERKELEY · PI SCOTT, KRISTIN E · 2013 to 2022
$2.9M
Howard Hughes Medical InstituteNIDCD NIH HHS DC013280NIDCD NIH HHS R01 DC013280
6 · The paper itself

Abstract

Gustatory receptors and peripheral taste cells have been identified in flies and mammals, revealing that sensory cells are tuned to taste modality across species. How taste modalities are processed in higher brain centers to guide feeding decisions is unresolved. Here, we developed a large-scale calcium-imaging approach coupled with cell labeling to examine how different taste modalities are processed in the fly brain. These studies reveal that sweet, bitter, and water sensory cells activate different cell populations throughout the subesophageal zone, with most cells responding to a single taste modality. Pathways for sweet and bitter tastes are segregated from sensory input to motor output, and this segregation is maintained in higher brain areas, including regions implicated in learning and neuromodulation. Our work reveals independent processing of appetitive and aversive tastes, suggesting that flies and mammals use a similar coding strategy to ensure innate responses to salient compounds.

Indexed as

Adenosine TriphosphateAnimalsAnimals, Genetically ModifiedBrainCalciumDose-Response Relationship, DrugDrosophilaDrosophila ProteinsEpithelial Sodium ChannelsFemaleGABA AntagonistsGene Expression RegulationNeuronsOrganophosphorus CompoundsReceptors, Cell SurfaceReceptors, Purinergic P2X23-aminopropyl(methyl)phosphinic acidAdenosine TriphosphateCalciumDrosophila ProteinsEpithelial Sodium ChannelsGABA AntagonistsOrganophosphorus CompoundsPPK28 protein, DrosophilaReceptors, Cell SurfaceReceptors, Purinergic P2X2SucroseSweetening Agents

Identifiers

PMID26051423
PMCPMC4474761

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.