Spatial discrimination reversal and incremental repeated acquisition in adolescent and adult BALB/c mice.

Andrew Nathanael Shen, Derek A Pope, Blake A Hutsell, M Christopher Newland

Open access · greenAbstract read

In one paragraph

Article in Behavioural processes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.6field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

Examination of clozapine and haloperidol in improving ketamine-induced deficits in an incremental repeated acquisition procedure in BALB/c mice.Psychopharmacology · 2016
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew Nathanael ShenDepartment of Psychology, Behavioral Toxicology Lab, Auburn University, USA. Electronic address: anshen14@gmail.com.

Derek A PopeDepartment of Psychology, Behavioral Toxicology Lab, Auburn University, USA.

Blake A HutsellDepartment of Psychology, Behavioral Toxicology Lab, Auburn University, USA; Department of Pharmacology and Toxicology, Virginia Commonwealth University, USA.

M Christopher NewlandDepartment of Psychology, Behavioral Toxicology Lab, Auburn University, USA. Electronic address: newlamc@auburn.edu.

Auburn University · US

Funding

NEUROTOXIC MECHANISMS OF METHYLMERCURY POISONINGR01ES003299 · NIEHS · MICHIGAN STATE UNIVERSITY · PI ATCHISON, WILLIAM D · 1985 to 2012

$5.5M

NIEHS NIH HHS ES003299NIEHS NIH HHS R01 ES003299

6 · The paper itself

Abstract

Adolescence is characterized by neural and behavior development that includes increases in novel experiences and impulsive choice. Experimental rodent models can characterize behavior phenotypes that typify adolescence. The present experiment was designed to characterize differences between adolescent (post-natal day (PND) 34-60) and adult (PND 70-96) BALB/c mice using a response-initiated spatial discrimination reversal (SDR) and incremental repeated acquisition of response chains (IRA) procedures. During SDR, adolescents omitted more trials and were slower to initiate trials than adults, but the age groups did not differ on accuracy and perseveration measures. During IRA, adolescents displayed poorer overall performance (measured by progress quotient), lower accuracy at individual chain links, and completed fewer long response chains (>3 links) than adults. In both procedures (SDR and IRA), the poorer performance of adolescents appeared to be related to the use of a response device that was spatially removed from reinforcer delivery. These results indicate that SDR and IRA performance can be established during the brief rodent adolescent period but that these two age groups' performances differ. We hypothesize that adolescent behavior is more sensitive than adult behavior to the spatiotemporal distance between response device and location of reinforcer delivery.

Indexed as

Age FactorsAnimalsBehavior Rating ScaleChoice BehaviorConditioning, OperantLearningMaleMiceMice, Inbred BALB CModels, AnimalSpatial NavigationSpatio-Temporal AnalysisAdolescentBalb/cIncremental repeated acquisitionSpatial discrimination reversal

Identifiers

PMID26051193

DOI10.1016/j.beproc.2015.06.005

PMCPMC4516686

OpenAlexW578062279

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.