ArticleFertility and sterility2015
Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC).
Article in Fertility and sterility, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06523543 (Ultra-early Identification of Fetal Chromosomal Characteristics From Extravillous-trophoblast Cells), which is not on this map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Ultra-early Identification of Fetal Chromosomal Characteristics From Extravillous-trophoblast Cells
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- The Least Understood Placental Galectins: Galectin-14 and Galectin-16 in Human Pregnancy and Placental Biology.Diagnostics (Basel, Switzerland) · 2026Review
- Trophoblast Retrieval from the Cervix (TRIC) Across Early Gestation: A Multi-Method Assessment of Extravillous Trophoblast Recovery.International journal of molecular sciences · 2026Article
- Review
- Human placentation: foundations and implications for reproductive endocrinology and infertility.Systems biology in reproductive medicine · 2025Review
- Whole-genome sequencing analysis in families with recurrent pregnancy loss: A pilot study.PloS one · 2023Article
- Bioinformatics Analysis Identifies Potential Related Genes in the Pathogenesis of Intrauterine Fetal Growth Retardation.Evolutionary bioinformatics online · 2022Article
- Overview and recent developments in cell-based noninvasive prenatal testing.Prenatal diagnosis · 2021Review
- Galectin-14 Promotes Trophoblast Migration and Invasion by Upregulating the Expression of MMP-9 and N-Cadherin.Frontiers in cell and developmental biology · 2021Article
- A systematic review to guide future efforts in the determination of genetic causes of pregnancy loss.Frontiers in reproductive health · 2021Article
- Considerations for whole exome sequencing unique to prenatal care.Human genetics · 2020Review
- Optimization Protocol of Fixation Method for Trophoblast Retrieval from the Cervix (TRIC): A Preliminary Study.Diagnostics (Basel, Switzerland) · 2020Article
- In vitro fertilization and embryo transfer alter human placental function through trophoblasts in early pregnancy.Molecular medicine reports · 2020Article
- Endocervical trophoblast for interrogating the fetal genome and assessing pregnancy health at five weeks.European journal of medical genetics · 2019Article
- Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.Human reproduction update · 2018Review
- The Role of Galectins as Modulators of Metabolism and Inflammation.Mediators of inflammation · 2018Review
- Article
- Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal.Science translational medicine · 2016Article
- Altered Biomarkers in Trophoblast Cells Obtained Noninvasively Prior to Clinical Manifestation of Perinatal Disease.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine the expression pattern of biomarker proteins in extravillous trophoblast (EVT) cells obtained noninvasively by trophoblast retrieval and isolation from the cervix (TRIC) in patients with early pregnancy loss compared with control patients with uncomplicated term delivery.
designCase-control study.
settingAcademic medical center. PATIENT(S): Women with either early pregnancy loss (EPL, n = 10) or an uncomplicated term delivery (N = 10). INTERVENTION(S): Endocervical specimens obtained from ongoing pregnancies at gestational ages of 5-10 weeks to generate an archive of EVT cells isolated by TRIC, with medical records examined to select specimens matched for gestational age at the time of endocervical sampling. MAIN OUTCOME MEASURE(S): Known serum biomarkers for adverse pregnancy outcome that are expressed by EVT cells were evaluated by semiquantitative immunocytochemistry, using antibodies against endoglin (ENG), FMS-like tyrosine kinase-1 (FLT-1), α-fetoprotein (AFP), pregnancy-associated plasma protein-A (PAPP-A), galectin-13 (LGALS13), galectin-14 (LGALS14), and placental growth factor (PGF). RESULT(S): The EVT purity was over 95% in all specimens, based on chorionic gonadotropin expression; however, the number of EVT cells obtained was significantly lower in women with EPL than the control group. There was a statistically significant elevation of AFP, ENG, and FLT-1, and statistically significant reduction of PAPP-A, LGALS14, and PGF in the EPL group compared with controls. CONCLUSION(S): In this pilot study, EVT cells isolated by TRIC early in gestation exhibited altered protein expression patterns before an EPL compared with uncomplicated term pregnancies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.