Observational studyLangenbeck's archives of surgery2015
Vitamin D level is not a predictor of hypocalcemia after total thyroidectomy.
Observational study in Langenbeck's archives of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05216419 (Study for Effectiveness in Prevention of Postoperative Hypocalcemia of Preoperative Oral Supplementation of Vitamin D), which is not on this map. Cited by 17 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study for Effectiveness in Prevention of Postoperative Hypocalcemia of Preoperative Oral Supplementation of Vitamin D (D-mac 30,000 IU) in Patients Undergoing Total Thyroidectomy
Who cites it
17 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Definition and diagnosis of postsurgical hypoparathyroidism after thyroid surgery: meta-analysis.BJS open · 2022Pooled it
- Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- A Meta-Analysis of Risk Factors for Transient and Permanent Hypocalcemia After Total Thyroidectomy.Frontiers in oncology · 2020Pooled it
- Huge variations in definition and reported incidence of postsurgical hypoparathyroidism: a systematic review.Endocrine · 2019Pooled it
- Role of oral calcium supplementation alone or with vitamin D in preventing post-thyroidectomy hypocalcaemia: A meta-analysis.Medicine · 2019Pooled it
- Risk factors and outcomes of incidental parathyroidectomy in thyroidectomy: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Trial
- Preoperative calcium and vitamin D supplementation may reduce postoperative hypocalcaemia after total thyroidectomy.Archives of medical science : AMS · 2025Article
- Predictors of postoperative complications following thyroidectomy: A systematic review.Surgery in practice and science · 2024Review
- Serum Parathyroid Hormone and Vitamin D Levels as Predictors of Hypocalcemia after Total/ Near Total Thyroidectomy.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- Risk Factors for Calcium-Phosphate Disorders after Thyroid Surgery.Biomedicines · 2023Article
- Can preoperative 25-hydroxyvitamin D levels predict transient hypocalcemia after total thyroidectomy?Updates in surgery · 2022Article
- The most reliable time point for intact parathyroid hormone measurement to predict hypoparathyroidism after total thyroidectomy with central neck dissection to treat papillary thyroid carcinoma: a prospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Article
- Routine low-dose calcium supplementation after thyroidectomy does not reduce the rate of symptomatic hypocalcemia: a prospective randomized trial.Annals of surgical treatment and research · 2019Article
- Incidence, prevalence and risk factors for post-surgical hypocalcaemia and hypoparathyroidism.Gland surgery · 2017Review
- Article
- IS THERE A RELATIONSHIP BETWEEN VITAMIN D STATUS AND HYPOCALCEMIA AFTER TOTAL THYROIDECTOMY?Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAs the incidence of thyroid cancer has increased, hypocalcemia, a common complication of thyroid surgery, has become a serious problem. However, no definite predictor of postoperative hypocalcemia is known. In this study, our purpose was to investigate the potential role of vitamin D as a predictor of postoperative hypocalcemia.
methodsA prospective observational study was performed on patients who underwent total thyroidectomy for thyroid cancer performed by a single experienced surgeon between October 2013 and September 2014. MEASUREMENTS: Their serum 25-OH vitamin D levels were measured preoperatively. On the day after surgery, serum calcium and intact parathyroid hormone levels were measured, and symptoms of hypocalcemia were recorded.
resultsOf the 134 patients, laboratory and symptomatic hypocalcemia developed in 52 patients (39 %) and 25 patients (19 %), on the day after surgery. The preoperative vitamin D level was 16.5 ± 9.2 ng/mL, and this value did not differ according to laboratory or symptomatic hypocalcemia (p = 0.94). The incidence of laboratory or symptomatic hypocalcemia did not differ according to vitamin D deficiency. Only incidental parathyroidectomy was associated with symptomatic hypocalcemia (p = 0.03).
conclusionsVitamin D level is not a predictor of hypocalcemia after total thyroidectomy for thyroid cancer. Thus, routine preoperative screening for vitamin D is not recommended.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.