Evidence map›Paper›PMID 26050963›Full record

ReviewBiochimica et biophysica acta2015

Gut bacteria and cancer.

Susan E Erdman, Theofilos Poutahidis

Registry-linked trialOpen access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03760653 (Physical Activity Along With a Probiotic for the Immune System and Quality of Life Improvement in Breast Cancer Survivor), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03760653 nawithdrawnnot on this mapstarted 2018, after this paper: background citation

Physical Activity Along With a Probiotic for the Immune System and Quality of Life Improvement in Breast Cancer Survivor: A Randomised Controlled Pilot Study

TypeinterventionalSponsorUniversidad Europea de MadridRan2018 to 2019Enrolled0ConditionsBreast Cancer FemalesArmsPhysical Exercise and probiotic group, Probiotic group, Placebo group
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Association of gut microbiomes with lung and esophageal cancer: a pilot study.World journal of microbiology & biotechnology · 2021
    Article
  12. Article
  13. Review
  14. Involvement ofInternational journal of molecular sciences · 2020
    Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Susan E ErdmanDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States. Electronic address: serdman@mit.edu.
Theofilos PoutahidisDivision of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States; Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54124, Greece.
Aristotle University of Thessaloniki · GRMassachusetts Institute of Technology · US

Funding

GI Tract Dysbiosis and Breast CancerU01CA164337 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E, WANG, TIMOTHY CRAGIN · 2012 to 2016
$2.6M
Role of IL10 and TGFb1 in colon cancerR01CA108854 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ERDMAN, SUSAN E · 2005 to 2014
$2.4M
NCI NIH HHS R01 CA108854NCI NIH HHS U01 CA164337
6 · The paper itself

Abstract

Microbiota on the mucosal surfaces of the gastrointestinal (GI) tract greatly outnumbers the cells in the human body. Effects of antibiotics indicate that GI tract bacteria may be determining the fate of distal cancers. Recent data implicate dysregulated host responses to enteric bacteria leading to cancers in extra-intestinal sites. Together these findings point to novel anti-cancer strategies aimed at promoting GI tract homeostasis.

Indexed as

BacteriaHumansInflammationInterleukin-6IntestinesNeoplasmsNeutrophilsInterleukin-6Breast cancerEntericImmune systemMammary cancerMicrobesNeutrophilsRegulatory T cells

Identifiers

PMID26050963
PMCPMC4940039
OpenAlexW2216908918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.