Evidence map›Paper›PMID 26050790›Full record

Trial reportBMC medicine2015

Effects of an 18-week exercise programme started early during breast cancer treatment: a randomised controlled trial.

Noémie Travier, Miranda J Velthuis, Charlotte N Steins Bisschop, Bram van den Buijs, Evelyn M Monninkhof, Frank Backx, Maartje Los, Frans Erdkamp, Haiko J Bloemendal, Carla Rodenhuis and 6 more

3 registry-linked trialsOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 107 papers, 30 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 30 pooled it
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03061773 nacompletednot on this map

Benefits of Physical Exercise in Patients With Breast Cancer

TypeinterventionalSponsorFederal University of MaranhaoRan2014 to 2015Enrolled2ConditionsBreast Cancer FemaleArmsExercise, Conventional hospital treatment
NCT03494400 nacompletednot on this mapstarted 2018, after this paper: background citation

Effects of Aerobic Training in Treatment for Breast Cancer

TypeinterventionalSponsorUniversidade Estadual Paulista Júlio de Mesquita FilhoRan2018 to 2020Enrolled6ConditionsCancer of Breast, HealthyArmsAerobic Training Presential, Aerobic Training Home-based
NCT06360809 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Prehabilitation Exercise Program in Breast Cancer: Effects on Quality of Life and Tumor Microenvironment (PEP_BC)

TypeinterventionalSponsorInstitut Nacional d'Educacio Fisica de CatalunyaRan2024 to 2025Enrolled76ConditionsBreast CancerArmsPrehabilitation exercise program
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 30 syntheses or guidelines pooled it, 233 citations in OpenAlex.

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  8. Impact of resistance training on fatigue among breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  10. Management of Fatigue in Adult Survivors of Cancer: ASCO-Society for Integrative Oncology Guideline Update.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Guideline
  11. Physical activity and pain in people with cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  14. Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  16. Impact on fatigue of different types of physical exercise during adjuvant chemotherapy and radiotherapy in breast cancer: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  17. Efficacy of resistance training during adjuvant chemotherapy and radiation therapy in cancer care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Noémie TravierJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands. ntravier@iconcologia.net.
Miranda J VelthuisComprehensive Cancer Organisation (IKNL), PO Box 19079, 3501 DB, Utrecht, The Netherlands. m.velthuis@iknl.nl.
Charlotte N Steins BisschopJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands. cnsteinsbisschop@gmail.com.
Bram van den BuijsDepartment of Rehabilitation, Nursing Sciences and Sport, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands. b.j.w.vandenbuijs@umcutrecht.nl.
Evelyn M MonninkhofJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands. e.monninkhof@umcutrecht.nl.
Frank BackxDepartment of Rehabilitation, Nursing Sciences and Sport, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands. f.j.g.backx@umcutrecht.nl.
Maartje LosMedical Oncology, St. Antonius Ziekenhuis, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands. m.los@antoniusziekenhuis.nl.
Frans ErdkampInternal Medicine - Medical Oncology, Obis Medisch Centrum, Dr vander Hoffplein 1, 6166 BG, Sittard-Geleen, The Netherlands. f.erdkamp@orbisconcern.nl.
Haiko J BloemendalDepartment of Internal Medicine, Medical Center, Maatweg 3, 3818 TZ, Amersfoort, The Netherlands. h.bloemendal@meandermc.nl.
Carla RodenhuisDepartment of Radiation Oncology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CG, Utrecht, The Netherlands. c.c.rodenhuis@umcutrecht.nl.
Marnix A J de RoosDepartment of Surgery, Ziekenhuis Rivierenland, President Kennedylaan 1, 4002 WP, Tiel, The Netherlands. m.de.roos@zrt.nl.
Marlies VerhaarDepartment of internal medicine, Hofpoort Ziekenhuis, Polanerbaan 2, 3447 GN, Woerden, The Netherlands. mverhaar@zuwehofpoort.nl.
Daan ten Bokkel HuininkInternal Medicine, Diakonessenhuis, Bosboomstraat 1, 3582 KE, Utrecht, The Netherlands. dtbokkelhuinink@diakhuis.nl.
Elsken van der WallCancer Center, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands. e.vanderwall@umcutrecht.nl.
Petra H M PeetersJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands. p.h.m.peeters@umcutrecht.nl.
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500, STR 6.131, 3508 GA, Utrecht, The Netherlands. a.m.may@umcutrecht.nl.
University Medical Center Utrecht · NLDiakonessenhuis hospital · NLHeidelberg University · DENetherlands Comprehensive Cancer Organisation · NLSt. Antonius Ziekenhuis · NLUniversity Hospital Heidelberg · DEZiekenhuis Rivierenland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercise started shortly after breast cancer diagnosis might prevent or diminish fatigue complaints. The Physical Activity during Cancer Treatment (PACT) study was designed to primarily examine the effects of an 18-week exercise intervention, offered in the daily clinical practice setting and starting within 6 weeks after diagnosis, on preventing an increase in fatigue.

methodsThis multi-centre controlled trial randomly assigned 204 breast cancer patients to usual care (n = 102) or supervised aerobic and resistance exercise (n = 102). By design, all patients received chemotherapy between baseline and 18 weeks. Fatigue (i.e., primary outcome at 18 weeks), quality of life, anxiety, depression, and physical fitness were measured at 18 and 36 weeks.

resultsIntention-to-treat mixed linear model analyses showed that physical fatigue increased significantly less during cancer treatment in the intervention group compared to control (mean between-group differences at 18 weeks: -1.3; 95 % CI -2.5 to -0.1; effect size -0.30). Results for general fatigue were comparable but did not reach statistical significance (-1.0, 95%CI -2.1; 0.1; effect size -0.23). At 18 weeks, submaximal cardiorespiratory fitness and several muscle strength tests (leg extension and flexion) were significantly higher in the intervention group compared to control, whereas peak oxygen uptake did not differ between groups. At 36 weeks these differences were no longer statistically significant. Quality of life outcomes favoured the exercise group but were not significantly different between groups.

conclusionsA supervised 18-week exercise programme offered early in routine care during adjuvant breast cancer treatment showed positive effects on physical fatigue, submaximal cardiorespiratory fitness, and muscle strength. Exercise early during treatment of breast cancer can be recommended. At 36 weeks, these effects were no longer statistically significant. This might have been caused by the control participants' high physical activity levels during follow-up.

trial registrationCurrent Controlled Trials ISRCTN43801571, Dutch Trial Register NTR2138. Trial registered on December 9th, 2009.

Indexed as

AdultAgedBreast NeoplasmsDepressionExercise TherapyFatigueFemaleHumansMiddle AgedMuscle StrengthPhysical FitnessQuality of Life

Identifiers

PMID26050790
PMCPMC4461906
OpenAlexW1595262291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.