ArticleInternational journal of epidemiology2015
Data Resource Profile: Clinical Practice Research Datalink (CPRD).
Article in International journal of epidemiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06444711 (A Randomised Clinical Trial for OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals and Evaluation of Outcomes), which is not on this map. Cited by 1,522 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomised Clinical Trial for OPTIMISation of Cardio-renal-metabolic-pulmonary Disease Guideline Adherence in High Risk Community Dwelling Individuals and Evaluation of Outcomes
Who cites it
1,522 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Blood-test monitoring strategies for patients established on immune-suppressing drugs: a mixed-methods study.Health technology assessment (Winchester, England) · 2026Pooled it
- Does early pregnancy exposure to macrolide antibiotics lead to major birth defects? A systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Insights and limitations of endometrial cancer risk prediction models for clinical applicability: a systematic review.BMC cancer · 2025Pooled it
- Parental mental illness and the risk of offspring cancer in childhood: a pooled meta-analysis of English and Swedish national cohorts.BMC psychiatry · 2025Pooled it
- Electronic medicine management systems in developing countries: A landscape review.British journal of clinical pharmacology · 2025Pooled it
- Effectiveness of surgical interventions in patients with severe pressure ulcers: the SIPS mixed-methods exploratory study.Health technology assessment (Winchester, England) · 2025Pooled it
- Opportunities and Challenges of Cardiovascular Disease Risk Prediction for Primary Prevention Using Machine Learning and Electronic Health Records: A Systematic Review.Reviews in cardiovascular medicine · 2025Pooled it
- Choosing real-world data for clinical and epidemiological research: methodological lessons from NHIRD and TriNetX-A narrative review.Annals of medicine · 2026Review
- Increasing Trends in Hospitalisation With Diabetic Ketoacidosis at Type 1 Diabetes Diagnosis Among Children and Youth in the United States and England, 2002-2020.Diabetes, obesity & metabolism · 2026Article
- Associations between osteoarthritis and comorbidities before and after diagnosis across four European primary care databases: a multinational case-control and cohort study.The Lancet regional health. Europe · 2026Article
- SGLT2 Inhibitor Use in Type 2 Diabetes in England: A Population-Based Cross-Sectional Study of Uptake of NICE Guidance.Diabetes, obesity & metabolism · 2026Observational
- Big data and psychiatry: advances, constraints and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Diabetes medication use in the last year of life in people living with dementia in the United Kingdom and Australia.European geriatric medicine · 2026Article
- Big Data and Artificial Intelligence in Cancer Drug Discovery: Promise, Challenges, and Emerging Opportunities.Cancers · 2026Review
- Prediction of incident heart failure in individuals without prior cardiovascular disease: the SCORE2-HF risk model.European heart journal · 2026Article
- Prediction of incident heart failure in established atherosclerotic cardiovascular disease: the SMART2-HF model.European heart journal · 2026Article
- Observational
- Incidence and prevalence of obstructive sleep apnoea and narcolepsy in the UK: a population-based descriptive study.Thorax · 2026Article
- Examining variations in adherence to guideline-recommended post-acute kidney injury care in primary care in England: a population-based cohort study.BMC medicine · 2026Article
- External Validation of SELECT Trial-Derived Cardiovascular Risk Equations in a UK Population with Overweight or Obesity and Established Cardiovascular Disease Without Diabetes.PharmacoEconomics · 2026Article
1,462 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
The Clinical Practice Research Datalink (CPRD) is an ongoing primary care database of anonymised medical records from general practitioners, with coverage of over 11.3 million patients from 674 practices in the UK. With 4.4 million active (alive, currently registered) patients meeting quality criteria, approximately 6.9% of the UK population are included and patients are broadly representative of the UK general population in terms of age, sex and ethnicity. General practitioners are the gatekeepers of primary care and specialist referrals in the UK. The CPRD primary care database is therefore a rich source of health data for research, including data on demographics, symptoms, tests, diagnoses, therapies, health-related behaviours and referrals to secondary care. For over half of patients, linkage with datasets from secondary care, disease-specific cohorts and mortality records enhance the range of data available for research. The CPRD is very widely used internationally for epidemiological research and has been used to produce over 1000 research studies, published in peer-reviewed journals across a broad range of health outcomes. However, researchers must be aware of the complexity of routinely collected electronic health records, including ways to manage variable completeness, misclassification and development of disease definitions for research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.