Evidence map›Paper›PMID 26050115›Full record

ReviewCurrent opinion in nephrology and hypertension2015

Pathophysiology of the chronic kidney disease-mineral bone disorder.

Keith A Hruska, Michael Seifert, Toshifumi Sugatani

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in nephrology and hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Meta-analyses of the quantitative computed tomography data in dialysis patients show differential impacts of renal failure on the trabecular and cortical bones.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  2. Trial
  3. Effects of sucroferric oxyhydroxide and sevelamer carbonate on chronic kidney disease-mineral bone disorder parameters in dialysis patients.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2019
    Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Bone-organ axes: bidirectional crosstalk.Military Medical Research · 2024
    Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Chronic Kidney Disease-Induced Vascular Calcification Impairs Bone Metabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
    Article
  17. The risk of medically uncontrolled secondary hyperparathyroidism depends on parathyroid hormone levels at haemodialysis initiation.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Article
  18. CKD-MBD post kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2021
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Keith A HruskaaDepartment of Pediatrics, Nephrology bDepartments of Medicine and Cell Biology Washington University Saint Louis, Saint Louis, Missouri cDepartment of Pediatrics, Nephrology, Southern Illinois University, Springfield, Illinois, USA.
Michael Seifert
Toshifumi Sugatani
Southern Illinois University School of Medicine · US

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Washington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8M
RENAL OSTEODYSTROPHY AND VASCULAR CALCIFICATIONR01DK070790 · NIDDK · WASHINGTON UNIVERSITY · PI HRUSKA, KEITH A · 2006 to 2018
$3.9M
CARDIOVASCULAR RISK MECHANISMS IN CKDR01DK089137 · NIDDK · WASHINGTON UNIVERSITY · PI HRUSKA, KEITH A · 2012 to 2016
$1.6M
NCATS NIH HHS KL2 TR000450NCATS NIH HHS UL1 TR000448NIDDK NIH HHS L40 DK099748NIDDK NIH HHS L40 DK099748-01NIDDK NIH HHS R01 DK070790NIDDK NIH HHS R01DK070790NIDDK NIH HHS R01 DK089137NIDDK NIH HHS R01DK089137
6 · The paper itself

Abstract

purpose of reviewThe causes of excess cardiovascular mortality associated with chronic kidney disease (CKD) have been attributed in part to the CKD-mineral bone disorder syndrome (CKD-MBD), wherein, novel cardiovascular risk factors have been identified. The causes of the CKD-MBD are not well known and they will be discussed in this review RECENT

findingsThe discovery of WNT (portmanteau of wingless and int) inhibitors, especially Dickkopf 1, produced during renal repair and participating in the pathogenesis of the vascular and skeletal components of the CKD-MBD implied that additional pathogenic factors are critical, leading to the finding that activin A is a second renal repair factor circulating in increased levels during CKD. Activin A derives from peritubular myofibroblasts of diseased kidneys, where it stimulates fibrosis, and decreases tubular klotho expression. The type 2 activin A receptor, ActRIIA, is decreased by CKD in atherosclerotic aortas, specifically in vascular smooth muscle cells (VSMC). Inhibition of activin signaling by a ligand trap inhibited CKD induced VSMC dedifferentiation, osteogenic transition and atherosclerotic calcification. Inhibition of activin signaling in the kidney decreased renal fibrosis and proteinuria. SUMMARY: These studies demonstrate that circulating renal repair factors are causal for the CKD-MBD and CKD associated cardiovascular disease, and identify ActRIIA signaling as a therapeutic target in CKD that links progression of renal disease and vascular disease.

Indexed as

AnimalsBone Diseases, MetabolicCardiovascular DiseasesHumansMineralsRenal Insufficiency, ChronicVascular CalcificationMinerals

Identifiers

PMID26050115
PMCPMC4699443
OpenAlexW1919757770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.