Evidence map›Paper›PMID 26050091›Full record

ArticleProtein & cell2015

LSY-2 is essential for maintaining the germ-soma distinction in C. elegans.

Long Lin, Yuping Li, Libo Yan, Gangming Zhang, Yu Zhao, Hong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Long LinCollege of Life Sciences, Beijing Normal University, Beijing, 100875, China.
Yuping Li
Libo Yan
Gangming Zhang
Yu Zhao
Hong Zhang

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.

Indexed as

Adenosine TriphosphatasesAnimalsAnimals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsFluorescent Antibody Technique, IndirectGene Expression ProfilingGenes, EssentialGerm CellsGreen Fluorescent ProteinsMutationRNA InterferenceTranscription FactorsAdenosine TriphosphatasesCaenorhabditis elegans ProteinsGreen Fluorescent ProteinsISWI proteinLsy-2 protein, C elegansMes-4 protein, C elegansTranscription Factors

Identifiers

PMID26050091
PMCPMC4506282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.