ArticleNeuron2015
Distinct Growth Factor Families Are Recruited in Unique Spatiotemporal Domains during Long-Term Memory Formation in Aplysia californica.
Article in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- The Right Time for a Synapse to Change: Windows and Mechanisms of Multiday Training Trials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Long-term dynamic profiles of cognitive kinases induced by different learning protocols.bioRxiv : the preprint server for biology · 2025Article
- Pattern detection in the TGFβ cascade controls the induction of long-term synaptic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dynamics and Mechanisms of ERK Activation after Different Protocols that Induce Long-Term Synaptic Facilitation inOxford open neuroscience · 2023Article
- Defective synaptic plasticity in a model of Coffin-Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways.Learning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Precise timing of ERK phosphorylation/dephosphorylation determines the outcome of trial repetition during long-term memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.Scientific reports · 2021Article
- ELAV Proteins Bind and Stabilize C/EBP mRNA in the Induction of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Repeating or spacing learning sessions are strategies for memory improvement with shared molecular and neuronal components.Neurobiology of learning and memory · 2020Article
- Postsynaptic effects ofLearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- The ELAV family of RNA-binding proteins in synaptic plasticity and long-term memory.Neurobiology of learning and memory · 2019Review
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats.Nature communications · 2018Article
- Selective Erasure of Distinct Forms of Long-Term Synaptic Plasticity Underlying Different Forms of Memory in the Same Postsynaptic Neuron.Current biology : CB · 2017Article
- The Spacing Effect for Structural Synaptic Plasticity Provides Specificity and Precision in Plastic Changes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Optimized solubilization of TRIzol-precipitated protein permits Western blotting analysis to maximize data available from brain tissue.Journal of neuroscience methods · 2017Article
- Cell-Specific PKM Isoforms Contribute to the Maintenance of Different Forms of Persistent Long-Term Synaptic Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory ineLife · 2017Article
- Transforming growth factor β recruits persistent MAPK signaling to regulate long-term memory consolidation in Aplysia californica.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- The Contribution of Spatial and Temporal Molecular Networks in the Induction of Long-term Memory and Its Underlying Synaptic Plasticity.AIMS neuroscience · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Several growth factors (GFs) have been implicated in long-term memory (LTM), but no single GF can support all of the plastic changes that occur during memory formation. Because GFs engage highly convergent signaling cascades that often mediate similar functional outcomes, the relative contribution of any particular GF to LTM is difficult to ascertain. To explore this question, we determined the unique contribution of distinct GF families (signaling via TrkB and TGF-βr-II) to LTM formation in Aplysia. We demonstrate that TrkB and TGF-βr-II signaling are differentially recruited during two-trial training in both time (by trial 1 or 2, respectively) and space (in distinct subcellular compartments). These GFs independently regulate MAPK activation and synergistically regulate gene expression. We also show that trial 1 TrkB and trial 2 TGF-βr-II signaling are required for LTM formation. These data support the view that GFs engaged in LTM formation are interactive components of a complex molecular network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.